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Ubiquitous regulation of cerebrovascular diseases by ubiquitin-modifying enzymes.
Huang, Jingyong; Zhu, Zhenhu; Schlüter, Dirk; Lambertsen, Kate Lykke; Song, Weihong; Wang, Xu.
Afiliación
  • Huang J; Department of Vascular Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
  • Zhu Z; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
  • Schlüter D; Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany.
  • Lambertsen KL; Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense C, Denmark.
  • Song W; BRIGDE-Brain Research-Inter-Disciplinary Guided Excellence, Department of Clinical Research, University of Southern Denmark, Odense C, Denmark.
  • Wang X; Department of Neurology, Odense University Hospital, Odense C, Denmark.
Clin Transl Med ; 14(5): e1719, 2024 May.
Article en En | MEDLINE | ID: mdl-38778460
ABSTRACT
Cerebrovascular diseases (CVDs) are a major threat to global health. Elucidation of the molecular mechanisms underlying the pathology of CVDs is critical for the development of efficacious preventative and therapeutic approaches. Accumulating studies have highlighted the significance of ubiquitin-modifying enzymes (UMEs) in the regulation of CVDs. UMEs are a group of enzymes that orchestrate ubiquitination, a post-translational modification tightly involved in CVDs. Functionally, UMEs regulate multiple pathological processes in ischemic and hemorrhagic stroke, moyamoya disease, and atherosclerosis. Considering the important roles of UMEs in CVDs, they may become novel druggable targets for these diseases. Besides, techniques applying UMEs, such as proteolysis-targeting chimera and deubiquitinase-targeting chimera, may also revolutionize the therapy of CVDs in the future.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos Cerebrovasculares Límite: Humans Idioma: En Revista: Clin Transl Med Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos Cerebrovasculares Límite: Humans Idioma: En Revista: Clin Transl Med Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos