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Prevalence and risk factors for HPV seropositivity and anogenital DNA positivity among men who have sex with men: a repeated cross-sectional study.
Kusters, Johannes M A; Obels, Ilja; van der Klis, Fiona R M; King, Audrey J; Heijman, Titia; Heijne, Janneke C M; van Benthem, Birgit H B; van der Loeff, Maarten F Schim.
Afiliación
  • Kusters JMA; Centre for Infectious Diseases Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands; Amsterdam Institute for Infection and Immunity (AII), Amsterdam UMC, Amsterdam, The Netherlands. Electronic address: jeroen.kusters@rivm.nl.
  • Obels I; Centre for Infectious Diseases Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
  • van der Klis FRM; Centre for Infectious Diseases Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
  • King AJ; Centre for Infectious Diseases Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
  • Heijman T; Department of Infectious Diseases, Public Health Service of Amsterdam, Amsterdam, The Netherlands.
  • Heijne JCM; Amsterdam Institute for Infection and Immunity (AII), Amsterdam UMC, Amsterdam, The Netherlands; Department of Infectious Diseases, Public Health Service of Amsterdam, Amsterdam, The Netherlands.
  • van Benthem BHB; Centre for Infectious Diseases Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
  • van der Loeff MFS; Amsterdam Institute for Infection and Immunity (AII), Amsterdam UMC, Amsterdam, The Netherlands; Department of Infectious Diseases, Public Health Service of Amsterdam, Amsterdam, The Netherlands.
Int J Infect Dis ; 145: 107094, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38777081
ABSTRACT

OBJECTIVES:

This study aimed to assess associations of potential risk factors with human papillomavirus (HPV) seropositivity among men who have sex with men (MSM) and compare these to risk factors for anal and penile (HPV) deoxyribonucleic acid (DNA)-positivity in the same study population.

METHODS:

Seropositivity and anal and penile HPV DNA-positivity were determined for seven high-risk HPV genotypes for MSM aged 16-24 years participating in Papillomavirus Surveillance among STI clinic Youngsters in the Netherlands (PASSYON) 2009-2021. Logistic regression models were conducted to assess risk factors for seropositivity, anal and penile HPV DNA-positivity.

RESULTS:

Overall, 1019 MSM were included. HPV-16 and -18 were most common for serology, and anal and penile HPV DNA-positivity. Although no clear similarities were observed for most risk factors for HPV seropositivity and anal or penile DNA positivity, receptive anal intercourse (RAI) was the strongest associated risk factor for both seropositivity ('RAI ever' adjusted odds ratio [aOR] 3.50, 95% confidence interval [CI] 1.56-7.88; 'RAI previous 6 months' aOR 2.17, 95% CI 1.44-3.26) and anal DNA-positivity ('RAI previous 6 months' aOR 1.67, 95% CI 1.09-2.56).

CONCLUSIONS:

Our study is suggestive of site-specific immune response after HPV infection; RAI might lead to anal HPV infections and consequently to seroconversion. Finally, as the two genotypes that are most oncogenic and preventable by all HPV vaccines were most common, our results underline the importance of gender-neutral vaccination.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Canal Anal / ADN Viral / Homosexualidad Masculina / Infecciones por Papillomavirus Límite: Adolescent / Adult / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Int J Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2024 Tipo del documento: Article Pais de publicación: Canadá
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Canal Anal / ADN Viral / Homosexualidad Masculina / Infecciones por Papillomavirus Límite: Adolescent / Adult / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Int J Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2024 Tipo del documento: Article Pais de publicación: Canadá