Your browser doesn't support javascript.
loading
Cardiac Autonomic Neuropathy in Graves' Disease: Smoking and Age as Predictive Factors.
Zuntini, José Victor Roveroni; Atala, Yeelen Ballesteros; Parisi, Maria Cândida Ribeiro; Oliveira, Daniela Camargo de; Zantut-Wittmann, Denise Engelbrecht.
Afiliación
  • Zuntini JVR; School of Medical Sciences, Pontifical Catholic University of Campinas, Campinas-SP, Brazil.
  • Atala YB; Endocrinology Division, Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas-SP, Brazil.
  • Parisi MCR; Endocrinology Division, Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas-SP, Brazil.
  • Oliveira DC; Cardiology Division, Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas-SP, Brazil.
  • Zantut-Wittmann DE; Endocrinology Division, Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas-SP, Brazil. Electronic address: zantutw@unicamp.br.
Endocr Pract ; 30(9): 822-829, 2024 Sep.
Article en En | MEDLINE | ID: mdl-38777033
ABSTRACT

OBJECTIVES:

Hypermetabolic state in Graves' disease (GD) has a great impact on heart homeostasis, acting directly on the heart muscle and modulating the autonomic nervous system. To characterize cardiac autonomic neuropathy (CAN) as a possible complication in patients with GD.

METHODS:

We evaluated euthyroid GD patients and a control group of healthy euthyroid people. CAN was assessed using autonomic tests of cardiovascular reflex and heart rate variability respiratory, Valsalva, orthostatic and orthostatic hypotension tests, high frequency, low frequency, and very low-frequency bands. Transthoracic echocardiography was performed in GD patients.

RESULTS:

Sixty GD patients and 50 people in control group were assessed. CAN was diagnosed in 20% of GD and 14% in the control group. Among GD, 13.3% presented incipient, and 6.7% established CAN, while in the control group, it was verified incipient in 8% and established in 6% (P = .7479). All GD patients with CAN presented an alteration in the deep breathing test. Age and smoking were evidenced as factors associated with the presence of CAN, while higher TRAb values at diagnosis decreased the chance of CAN.

CONCLUSIONS:

The prevalence of CAN in euthyroid GD patients was 20%. Changes in the cardiac autonomic nervous system were identified, pointing to the importance of evaluating this complication in these patients. Smoking was a predictive factor for CAN, increasing its relationship with conditions that aggravate GD.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades del Sistema Nervioso Autónomo / Fumar / Enfermedad de Graves Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Endocr Pract Asunto de la revista: ENDOCRINOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades del Sistema Nervioso Autónomo / Fumar / Enfermedad de Graves Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Endocr Pract Asunto de la revista: ENDOCRINOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos