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Long-Term Exposure to Fine Particulate Matter and Fasting Blood Glucose and Diabetes in 20 Million Chinese Women of Reproductive Age.
Shen, Yang; Jiang, Lifang; Xie, Xiaoxu; Meng, Xia; Xu, Xianrong; Dong, Jing; Yang, Ying; Xu, Jihong; Zhang, Ya; Wang, Qiaomei; Shen, Haiping; Zhang, Yiping; Yan, Donghai; Zhou, Lu; Jiang, Yixuan; Chen, Renjie; Kan, Haidong; Cai, Jing; He, Yuan; Ma, Xu.
Afiliación
  • Shen Y; Key Laboratory of Public Health Safety of the Ministry of Education and National Health Commission Key Laboratory of Health Technology Assessment, School of Public Health, Fudan University, Shanghai, China.
  • Jiang L; National Health Commission Key Laboratory of Birth Defects Prevention, Henan Key Laboratory of Population Defects Prevention, Henan Institute of Reproduction Health Science and Technology, Zhengzhou, China.
  • Xie X; Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, China.
  • Meng X; Key Laboratory of Public Health Safety of the Ministry of Education and National Health Commission Key Laboratory of Health Technology Assessment, School of Public Health, Fudan University, Shanghai, China.
  • Xu X; School of Public Health, Hangzhou Normal University, Hangzhou, China.
  • Dong J; National Research Institute for Family Planning, Beijing, China.
  • Yang Y; National Human Genetic Resources Center, Beijing, China.
  • Xu J; National Research Institute for Family Planning, Beijing, China.
  • Zhang Y; National Human Genetic Resources Center, Beijing, China.
  • Wang Q; National Research Institute for Family Planning, Beijing, China.
  • Shen H; National Human Genetic Resources Center, Beijing, China.
  • Zhang Y; National Research Institute for Family Planning, Beijing, China.
  • Yan D; National Human Genetic Resources Center, Beijing, China.
  • Zhou L; Department of Maternal and Child Health, National Health Commission of the People's Republic of China, Beijing, China.
  • Jiang Y; Department of Maternal and Child Health, National Health Commission of the People's Republic of China, Beijing, China.
  • Chen R; Department of Maternal and Child Health, National Health Commission of the People's Republic of China, Beijing, China.
  • Kan H; Department of Maternal and Child Health, National Health Commission of the People's Republic of China, Beijing, China.
  • Cai J; Key Laboratory of Public Health Safety of the Ministry of Education and National Health Commission Key Laboratory of Health Technology Assessment, School of Public Health, Fudan University, Shanghai, China.
  • He Y; Key Laboratory of Public Health Safety of the Ministry of Education and National Health Commission Key Laboratory of Health Technology Assessment, School of Public Health, Fudan University, Shanghai, China.
  • Ma X; Key Laboratory of Public Health Safety of the Ministry of Education and National Health Commission Key Laboratory of Health Technology Assessment, School of Public Health, Fudan University, Shanghai, China.
Diabetes Care ; 47(8): 1400-1407, 2024 Aug 01.
Article en En | MEDLINE | ID: mdl-38776453
ABSTRACT

OBJECTIVE:

Evidence of the associations between fine particulate matter (PM2.5) and diabetes risk from women of reproductive age, in whom diabetes may have adverse long-term health effects for both themselves and future generations, remains scarce. We therefore examined the associations of long-term PM2.5 exposure with fasting blood glucose (FBG) level and diabetes risk in women of reproductive age in China. RESEARCH DESIGN AND

METHODS:

This study included 20,076,032 women age 20-49 years participating in the National Free Preconception Health Examination Project in China between 2010 and 2015. PM2.5 was estimated using a satellite-based model. Multivariate linear and logistic regression models were used to examine the associations of PM2.5 exposure with FBG level and diabetes risk, respectively. Diabetes burden attributable to PM2.5 was estimated using attributable fraction (AF) and attributable number.

RESULTS:

PM2.5 showed monotonic relationships with elevated FBG level and diabetes risk. Each interquartile range (27 µg/m3) increase in 3-year average PM2.5 concentration was associated with a 0.078 mmol/L (95% CI 0.077, 0.079) increase in FBG and 18% (95% CI 16%, 19%) higher risk of diabetes. The AF attributed to PM2.5 exposure exceeding 5 µg/m3 was 29.0% (95% CI 27.5%, 30.5%), corresponding to an additional 78.6 thousand (95% CI 74.5, 82.6) diabetes cases. Subgroup analyses showed more pronounced diabetes risks in those who were overweight or obese, age >35 years, less educated, of minority ethnicity, registered as a rural household, and residing in western China.

CONCLUSIONS:

We found long-term PM2.5 exposure was associated with higher diabetes risk in women of reproductive age in China.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glucemia / Material Particulado Límite: Adult / Female / Humans / Middle aged País/Región como asunto: Asia Idioma: En Revista: Diabetes Care Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glucemia / Material Particulado Límite: Adult / Female / Humans / Middle aged País/Región como asunto: Asia Idioma: En Revista: Diabetes Care Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos