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Natural L-type calcium channels antagonists from Chinese medicine.
Xu, Fangfang; Cai, Wanna; Liu, Bo; Qiu, Zhenwen; Zhang, Xiaoqi.
Afiliación
  • Xu F; The Second Clinical College , Guangzhou University of Chinese Medicine, Guangzhou, 510006, People's Republic of China.
  • Cai W; The Second Clinical College , Guangzhou University of Chinese Medicine, Guangzhou, 510006, People's Republic of China.
  • Liu B; The Second Clinical College , Guangzhou University of Chinese Medicine, Guangzhou, 510006, People's Republic of China.
  • Qiu Z; The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, 510405, People's Republic of China. zhenwen@gzucm.edu.cn.
  • Zhang X; Guangdong Provincial Engineering Research Center for Modernization of TCM, NMPA Key Laboratory for Quality Evaluation of TCM, Jinan University, Guangzhou, 510632, People's Republic of China. tzhxq01@jnu.edu.cn.
Chin Med ; 19(1): 72, 2024 May 21.
Article en En | MEDLINE | ID: mdl-38773596
ABSTRACT
L-type calcium channels (LTCCs), the largest subfamily of voltage-gated calcium channels (VGCCs), are the main channels for Ca2+ influx during extracellular excitation. LTCCs are widely present in excitable cells, especially cardiac and cardiovascular smooth muscle cells, and participate in various Ca2+-dependent processes. LTCCs have been considered as worthy drug target for cardiovascular, neurological and psychological diseases for decades. Natural products from Traditional Chinese medicine (TCM) have shown the potential as new drugs for the treatment of LTCCs related diseases. In this review, the basic structure, function of LTCCs, and the related human diseases caused by structural or functional abnormalities of LTCCs, and the natural LTCCs antagonist and their potential usages were summarized.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chin Med Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chin Med Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido