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Coeliac disease and type 2 diabetes risk: a nationwide matched cohort and Mendelian randomisation study.
Yuan, Shuai; Leffler, Dan; Lebwohl, Benjamin; Green, Peter H R; Sun, Jiangwei; Carlsson, Sofia; Larsson, Susanna C; Ludvigsson, Jonas F.
Afiliación
  • Yuan S; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. shuai.yuan@ki.se.
  • Leffler D; The Celiac Center at Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Lebwohl B; Department of Medicine, Celiac Disease Center at Columbia University Medical Center, New York, NY, USA.
  • Green PHR; Departments of Medicine and Surgical Pathology, Columbia University College of Physicians and Surgeons, New York, NY, USA.
  • Sun J; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  • Carlsson S; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Larsson SC; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Ludvigsson JF; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Diabetologia ; 67(8): 1630-1641, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38772918
ABSTRACT
AIMS/

HYPOTHESIS:

While the association between coeliac disease and type 1 diabetes is well documented, the association of coeliac disease with type 2 diabetes risk remains undetermined. We conducted a nationwide cohort and Mendelian randomisation analysis to investigate this link.

METHODS:

This nationwide matched cohort used data from the Swedish ESPRESSO cohort including 46,150 individuals with coeliac disease and 219,763 matched individuals in the comparator group selected from the general population, followed up from 1969 to 2021. Data from 9053 individuals with coeliac disease who underwent a second biopsy were used to examine the association between persistent villous atrophy and type 2 diabetes. Multivariable Cox regression was employed to estimate the associations. In Mendelian randomisation analysis, 37 independent genetic variants associated with clinically diagnosed coeliac disease at p<5×10-8 were used to proxy genetic liability to coeliac disease. Summary-level data for type 2 diabetes were obtained from the DIAGRAM consortium (80,154 cases) and the FinnGen study (42,593 cases).

RESULTS:

Over a median 15.7 years' follow-up, there were 6132 (13.3%) and 30,138 (13.7%) incident cases of type 2 diabetes in people with coeliac disease and comparator individuals, respectively. Those with coeliac disease were not at increased risk of incident type 2 diabetes with an HR of 1.00 (95% CI 0.97, 1.03) compared with comparator individuals. Persistent villous atrophy was not associated with an increased risk of type 2 diabetes compared with mucosal healing among participants with coeliac disease (HR 1.02, 95% CI 0.90, 1.16). Genetic liability to coeliac disease was not associated with type 2 diabetes in DIAGRAM (OR 1.01, 95% CI 0.99, 1.03) or in FinnGen (OR 1.01, 95% CI 0.99-1.04). CONCLUSIONS/

INTERPRETATION:

Coeliac disease was not associated with type 2 diabetes risk.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad Celíaca / Diabetes Mellitus Tipo 2 / Análisis de la Aleatorización Mendeliana Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Diabetologia Año: 2024 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad Celíaca / Diabetes Mellitus Tipo 2 / Análisis de la Aleatorización Mendeliana Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Diabetologia Año: 2024 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Alemania