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Prevalence of nonalcoholic fatty liver disease in pediatrics and adolescents: a systematic review and meta-analysis.
Lee, Eun Joo; Choi, Miyoung; Ahn, Sang Bong; Yoo, Jeong-Ju; Kang, Seong Hee; Cho, Yuri; Song, Do Seon; Koh, Hong; Jeon, Dae Won; Lee, Hye Won.
Afiliación
  • Lee EJ; Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
  • Choi M; Clinical Evidence Research, National Evidence-Based Healthcare Collaborating Agency (NECA), Seoul, Korea.
  • Ahn SB; Department of Internal Medicine, Nowon Eulji Medical Center, Eulji University College of Medicine, Seoul, Korea.
  • Yoo JJ; Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.
  • Kang SH; Department of Internal Medicine, Sangkye Paek Hospital, Inje University College of Medicine, Seoul, Korea.
  • Cho Y; Center for Liver and Pancreatobiliary Cancer, National Cancer Center, Goyang, Korea.
  • Song DS; Department of Internal Medicine, College of Medicine, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Korea.
  • Koh H; Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
  • Jeon DW; Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea. noshin@hanyang.ac.kr.
  • Lee HW; Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. lorry-lee@yuhs.ac.
World J Pediatr ; 20(6): 569-580, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38771552
ABSTRACT

BACKGROUND:

As childhood obesity escalates worldwide, the prevalence of nonalcoholic fatty liver disease (NAFLD) in pediatric and adolescent populations is also increasing. However, systematic studies and meta-analyses evaluating the prevalence of pediatric NAFLD remain limited.

METHODS:

The MEDLINE, Korean Medical Database (KMBASE), Embase, Global Health, and Cochrane Library databases were searched from January 1997 to April 2023. Search terms included NAFLD or steatosis; nonalcoholic or steatohepatitis; child(ren), adolescent, or teenager; and prevalence, incidence, or epidemiology. A random-effects meta-analysis model was used to estimate the prevalence of pediatric NAFLD.

RESULTS:

A total of 2116 publications were found, of which 62 were included in the meta-analysis. Among them, 27 reported the prevalence in the general population and 39 in the obese population. The worldwide pooled prevalence of pediatric NAFLD was 13% [95% confidence interval (CI) 9-18%] in the general population and 47% (95% CI 41%-53%) in the obese population. Among 16 studies in the general population and 18 in the obese population, NAFLD prevalence varied by gender. In the general population, the prevalence of NAFLD was 15% (95% CI 8%-23%) in males and 10% (95% CI 6%-15%) in females. In the obese population, it was 54% (95% CI 46%-61%) in males and 39% (95% CI 30%-49%) in females.

CONCLUSIONS:

The global prevalence of pediatric NAFLD is rising in both the general and obese populations. Given the increasing rates of childhood obesity, epidemiological studies on the prevalence and incidence of NAFLD are needed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad del Hígado Graso no Alcohólico Límite: Adolescent / Child / Humans Idioma: En Revista: World J Pediatr Asunto de la revista: PEDIATRIA Año: 2024 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad del Hígado Graso no Alcohólico Límite: Adolescent / Child / Humans Idioma: En Revista: World J Pediatr Asunto de la revista: PEDIATRIA Año: 2024 Tipo del documento: Article Pais de publicación: Suiza