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The vaginal microbiome composition during pregnancy in a region compromising different ethnic origins.
Ozcan, Gulin; Vatansever, Cansel; Paerhati, Erxiati; Turgal, Mert; Gursoy, Tugba; Cekic, Sebile Güler; Unal, Ceren; Ozek, Murat Aykut; Gürsoy, Attila; Keskin, Özlem; Can, Fusun; Celik, Ebru.
Afiliación
  • Ozcan G; Department of Medicine, Division of Gastroenterology and Hepatology, University of Illinois at Chicago, Chicago, IL, USA.
  • Vatansever C; Koç University IsBank Research Center for Infectious Diseases (KUISCID), Istanbul, Turkey.
  • Paerhati E; Koç University IsBank Research Center for Infectious Diseases (KUISCID), Istanbul, Turkey.
  • Turgal M; College of Engineering, Koç University, Istanbul, Turkey.
  • Gursoy T; Department of Obstetrics and Gynecology, School of Medicine, Koc University, Zeytinburnu, Istanbul, Turkey.
  • Cekic SG; Department of Pediatrics, School of Medicine, Koc University, Istanbul, Turkey.
  • Unal C; Department of Obstetrics and Gynecology, School of Medicine, Koc University, Zeytinburnu, Istanbul, Turkey.
  • Ozek MA; Department of Obstetrics and Gynecology, School of Medicine, Koc University, Zeytinburnu, Istanbul, Turkey.
  • Gürsoy A; Department of Obstetrics and Gynecology, School of Medicine, Koc University, Zeytinburnu, Istanbul, Turkey.
  • Keskin Ö; College of Engineering, Koç University, Istanbul, Turkey.
  • Can F; College of Engineering, Koç University, Istanbul, Turkey.
  • Celik E; Koç University IsBank Research Center for Infectious Diseases (KUISCID), Istanbul, Turkey.
Arch Gynecol Obstet ; 310(1): 369-375, 2024 07.
Article en En | MEDLINE | ID: mdl-38771532
ABSTRACT

BACKGROUND:

The vaginal microbiota plays a significant role in pregnancy outcomes and newborn health. Indeed, the composition and diversity of the vaginal microbiota can vary among different ethnic groups. Our study aimed to investigate the composition of the vaginal microbiome throughout the three trimesters of pregnancy and to identify any potential variations or patterns in the Turkish population compromising mixed ethnicities.

METHOD:

We conducted a longitudinal study to characterize the vaginal microbiota of pregnant women. The study included a total of 25 participants, and the samples were collected at each trimester 11-13 weeks, 20-24 weeks and 28-34 weeks gestation.

RESULTS:

Lactobacillus species were consistently found to be dominant in the vaginal microbiota throughout all trimesters of pregnancy. Among Lactobacillus species, L. crispatus had the highest abundance in all trimesters (40.6%, 40.8% and 44.4%, respectively). L. iners was the second most prevalent species (28.5%, 31% and 25.04, respectively). Our findings reveal that the dominant composition of the vaginal microbiota aligns with the CST-type I, commonly observed in the European population.

CONCLUSIONS:

This suggests that there are shared mechanisms influencing the microbial communities in the vagina, which are likely influenced by factors such as genetics, lifestyle, and cultural behaviors rather than ethnicity alone. The complex interplay of these factors contributes to the establishment and maintenance of the vaginal microbiota during pregnancy. Understanding the underlying mechanisms and their impact on vaginal health across diverse populations is essential for improving pregnancy outcomes. The study was approved by the Koc University Ethical Committee (no2019.093.IRB2.030) and registered at the clinical trials.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vagina / Microbiota / Lactobacillus Límite: Adult / Female / Humans / Pregnancy País/Región como asunto: Asia / Europa Idioma: En Revista: Arch Gynecol Obstet Asunto de la revista: GINECOLOGIA / OBSTETRICIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vagina / Microbiota / Lactobacillus Límite: Adult / Female / Humans / Pregnancy País/Región como asunto: Asia / Europa Idioma: En Revista: Arch Gynecol Obstet Asunto de la revista: GINECOLOGIA / OBSTETRICIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania