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Glycyrrhizic Acid Alleviates Semen Strychni-Induced Neurotoxicity Through the Inhibition of HMGB1 Phosphorylation and Inflammatory Responses.
Yu, Changwei; Xiang, Yalan; Zhang, Min; Wen, Jing; Duan, Xiaoyu; Wang, Lu; Deng, Gongying; Fang, Pingfei.
Afiliación
  • Yu C; Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha, 410011, China.
  • Xiang Y; Institute of Clinical Pharmacy, Central South University, Changsha, 410011, China.
  • Zhang M; Department of Pharmacy, Hunan Provincial Maternal and Child Health Care Hospital, Changsha, 410008, China.
  • Wen J; Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha, 410011, China.
  • Duan X; Institute of Clinical Pharmacy, Central South University, Changsha, 410011, China.
  • Wang L; Department of Pharmacy, the Third Hospital of Changsha, Changsha, 410015, China.
  • Deng G; Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha, 410011, China.
  • Fang P; Institute of Clinical Pharmacy, Central South University, Changsha, 410011, China.
J Neuroimmune Pharmacol ; 19(1): 21, 2024 May 21.
Article en En | MEDLINE | ID: mdl-38771510
ABSTRACT
The neurotoxicity of Semen Strychni has been reported recently in several clinical cases. Therefore, this study was conducted to investigate the role of HMGB1 in a model of neurotoxicity induced by Semen Strychni and to assess the potential alleviating effects of glycyrrhizic acid (GA), which is associated with the regulation of HMGB1 release. Forty-eight SD rats were intraperitoneally injected with Semen Strychni extract (175 mg/kg), followed by oral administration of GA (50 mg/kg) for four days. After treatment of SS and GA, neuronal degeneration, apoptosis, and necrosis were observed via histopathological examination. Inflammatory cytokines (TNF-α and IL-1ß), neurotransmitter associated enzymes (MAO and AChE), serum HMGB1, nuclear and cytoplasmic HMGB1/ph-HMGB1, and the interaction between PP2A, PKC, and HMGB1 were evaluated. The influence of the MAPK pathway was also examined. As a result, this neurotoxicity was characterized by neuronal degeneration and apoptosis, the induction of pro-inflammatory cytokines, and a reduction in neurotransmitter-metabolizing enzymes. In contrast, GA treatment significantly ameliorated the abovementioned effects and alleviated nerve injury. Furthermore, Semen Strychni promoted HMGB1 phosphorylation and its translocation between the nucleus and cytoplasm, thereby activating the NF-κB and MAPK pathways, initiating various inflammatory responses. Our experiments demonstrated that GA could partially reverse these effects. In summary, GA acid alleviated Semen Strychni-induced neurotoxicity, possibly by inhibiting HMGB1 phosphorylation and preventing its release from the cell.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ratas Sprague-Dawley / Ácido Glicirrínico / Proteína HMGB1 Límite: Animals Idioma: En Revista: J Neuroimmune Pharmacol Asunto de la revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA / NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ratas Sprague-Dawley / Ácido Glicirrínico / Proteína HMGB1 Límite: Animals Idioma: En Revista: J Neuroimmune Pharmacol Asunto de la revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA / NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos