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Specialization of anterior and posterior hippocampal functional connectivity differs in autism.
Kember, J; Patenaude, P; Sweatman, H; Van Schaik, L; Tabuenca, Z; Chai, X J.
Afiliación
  • Kember J; Department of Neurology and Neurosurgery, McGill University, Montreal, Canada.
  • Patenaude P; Department of Neurology and Neurosurgery, McGill University, Montreal, Canada.
  • Sweatman H; Department of Neurology and Neurosurgery, McGill University, Montreal, Canada.
  • Van Schaik L; Department of Neurology and Neurosurgery, McGill University, Montreal, Canada.
  • Tabuenca Z; Department of Neurology and Neurosurgery, McGill University, Montreal, Canada.
  • Chai XJ; Department of Statistics, University of Zaragoza, Zaragoza, Spain.
Autism Res ; 17(6): 1126-1139, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38770780
ABSTRACT
Structural and functional differences in the hippocampus have been related to the episodic memory and social impairments observed in autism spectrum disorder (ASD). In neurotypical individuals, hippocampal-cortical functional connectivity systematically varies between anterior and posterior hippocampus, with changes observed during typical development. It remains unknown whether this specialization of anterior-posterior hippocampal connectivity is disrupted in ASD, and whether age-related differences in this specialization exist in ASD. We examined connectivity of the anterior and posterior hippocampus in an ASD (N = 139) and non-autistic comparison group (N = 133) aged 5-21 using resting-state functional magnetic resonance imaging (MRI) data from the Healthy Brain Network (HBN). Consistent with previous results, we observed lower connectivity between the whole hippocampus and medial prefrontal cortex in ASD. Moreover, preferential connectivity of the posterior relative to the anterior hippocampus for memory-sensitive regions in posterior parietal cortex was reduced in ASD, demonstrating a weaker anterior-posterior specialization of hippocampal-cortical connectivity. Finally, connectivity between the posterior hippocampus and precuneus negatively correlated with age in the ASD group but remained stable in the comparison group, suggesting an altered developmental specialization. Together, these differences in hippocampal-cortical connectivity may help us understand the neurobiological basis of the memory and social impairments found in ASD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Trastorno del Espectro Autista / Hipocampo Límite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Autism Res Asunto de la revista: PSIQUIATRIA / TRANSTORNOS MENTAIS Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Trastorno del Espectro Autista / Hipocampo Límite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Autism Res Asunto de la revista: PSIQUIATRIA / TRANSTORNOS MENTAIS Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos