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DNA damage response in brain tumors: A Society for Neuro-Oncology consensus review on mechanisms and translational efforts in neuro-oncology.
Rahman, Rifaquat; Shi, Diana D; Reitman, Zachary J; Hamerlik, Petra; de Groot, John F; Haas-Kogan, Daphne A; D'Andrea, Alan D; Sulman, Erik P; Tanner, Kirk; Agar, Nathalie Y R; Sarkaria, Jann N; Tinkle, Christopher L; Bindra, Ranjit S; Mehta, Minesh P; Wen, Patrick Y.
Afiliación
  • Rahman R; Department of Radiation Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Shi DD; Department of Radiation Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Reitman ZJ; Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA.
  • Hamerlik P; Division of Cancer Sciences, University of Manchester, Manchester, UK.
  • de Groot JF; Division of Neuro-Oncology, University of California San Francisco, San Francisco, California, USA.
  • Haas-Kogan DA; Department of Radiation Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • D'Andrea AD; Department of Radiation Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Sulman EP; Department of Radiation Oncology, New York University, New York, New York, USA.
  • Tanner K; National Brain Tumor Society, Newton, Massachusetts, USA.
  • Agar NYR; Department of Neurosurgery and Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Sarkaria JN; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA.
  • Tinkle CL; Department of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
  • Bindra RS; Department of Therapeutic Radiology, Yale University, New Haven, Connecticut, USA.
  • Mehta MP; Miami Cancer Institute, Baptist Hospital, Miami, Florida, USA.
  • Wen PY; Center for Neuro-Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
Neuro Oncol ; 26(8): 1367-1387, 2024 Aug 05.
Article en En | MEDLINE | ID: mdl-38770568
ABSTRACT
DNA damage response (DDR) mechanisms are critical to maintenance of overall genomic stability, and their dysfunction can contribute to oncogenesis. Significant advances in our understanding of DDR pathways have raised the possibility of developing therapies that exploit these processes. In this expert-driven consensus review, we examine mechanisms of response to DNA damage, progress in development of DDR inhibitors in IDH-wild-type glioblastoma and IDH-mutant gliomas, and other important considerations such as biomarker development, preclinical models, combination therapies, mechanisms of resistance and clinical trial design considerations.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Daño del ADN / Neoplasias Encefálicas Límite: Animals / Humans Idioma: En Revista: Neuro Oncol Asunto de la revista: NEOPLASIAS / NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Daño del ADN / Neoplasias Encefálicas Límite: Animals / Humans Idioma: En Revista: Neuro Oncol Asunto de la revista: NEOPLASIAS / NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido