Your browser doesn't support javascript.
loading
Association Between Insulin Resistance Indices and Liver Function Parameters Among Women With Polycystic Ovary Syndrome.
Saei Ghare Naz, Marzieh; Mousavi, Maryam; Firouzi, Faezeh; Momenan, Amir Abbas; Azizi, Fereidoun; Ramezani Tehrani, Fahimeh.
Afiliación
  • Saei Ghare Naz M; Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Mousavi M; Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Firouzi F; Department of Pathology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Momenan AA; Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Azizi F; Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Ramezani Tehrani F; Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Endocrinol Diabetes Metab ; 7(3): e490, 2024 May.
Article en En | MEDLINE | ID: mdl-38769719
ABSTRACT

OBJECTIVE:

This study aimed to investigate whether polycystic ovary syndrome (PCOS) status changes the association between insulin resistance (IR) indices and liver function parameters among women.

METHODS:

This is a cross-sectional, population-based study. We selected 1101 subjects aged ≥20 years from participants of Tehran Lipid and Glucose Study (TLGS). All of them had known the status of PCOS, and all variables were related to the IR indices and liver function parameters. The main outcome measures were TG/HDL-C and triglyceride-glucose (TyG) and liver function parameters (hepatic steatosis index [HSI], alanine transaminase [ALT] and aspartate transaminase [AST]).

RESULT:

In the present study, there was no significant difference between the PCOS and the non-PCOS regarding the presence of liver function abnormalities. A model adjusted by age and BMI showed that the upper tertile of TyG index was positively associated with high AST (OR = 3.04 [95% CI 1.20-7.68], p < 0.05), high ALT (4.76 [3.07-7.36], p < 0.05) and high HSI (8.44 [1.82-39.17], p < 0.05). Although the history of diabetes had a positive impact on elevated AST (1.66 [1.15, 2.40], p < 0.05), the third tertile of TG/HDL-C was associated with increased odds of elevated ALT (3.35 [2.21-5.06]) and HSI (6.55 [1.17-36.46]), whereas the second tertile of TG/HDL-C (OR = 2.65, CI 95% 1.74-4.03) was also positively associated with elevated ALT. PCOS had no significant association with elevated liver function tests.

CONCLUSION:

The highest tertile of TyG index and the TG/HDL-C ratio as a surrogate of IR might play a role in detecting abnormalities of liver function parameters among women. However, PCOS status cannot change the association between IR and liver dysfunction.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome del Ovario Poliquístico / Triglicéridos / Resistencia a la Insulina / Alanina Transaminasa / Hígado / Pruebas de Función Hepática Límite: Adult / Female / Humans País/Región como asunto: Asia Idioma: En Revista: Endocrinol Diabetes Metab Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome del Ovario Poliquístico / Triglicéridos / Resistencia a la Insulina / Alanina Transaminasa / Hígado / Pruebas de Función Hepática Límite: Adult / Female / Humans País/Región como asunto: Asia Idioma: En Revista: Endocrinol Diabetes Metab Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Reino Unido