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Grape Pomace Polyphenols Reduce Acute Inflammatory Response Induced by Carrageenan in a Murine Model.
Nery-Flores, Sendar Daniel; Castro-López, Cristina Marisela; Martínez-Hernández, Lucía; García-Chávez, Clara Victoria; Palomo-Ligas, Lissethe; Ascacio-Valdés, Juan Alberto; Flores-Gallegos, Adriana Carolina; Campos-Múzquiz, Lizeth Guadalupe; Rodríguez-Herrera, Raúl.
Afiliación
  • Nery-Flores SD; School of Chemistry, Universidad Autonoma de Coahuila, Saltillo, Coahuila, 25280, México.
  • Castro-López CM; School of Chemistry, Universidad Autonoma de Coahuila, Saltillo, Coahuila, 25280, México.
  • Martínez-Hernández L; School of Chemistry, Universidad Autonoma de Coahuila, Saltillo, Coahuila, 25280, México.
  • García-Chávez CV; School of Chemistry, Universidad Autonoma de Coahuila, Saltillo, Coahuila, 25280, México.
  • Palomo-Ligas L; School of Chemistry, Universidad Autonoma de Coahuila, Saltillo, Coahuila, 25280, México.
  • Ascacio-Valdés JA; School of Chemistry, Universidad Autonoma de Coahuila, Saltillo, Coahuila, 25280, México.
  • Flores-Gallegos AC; School of Chemistry, Universidad Autonoma de Coahuila, Saltillo, Coahuila, 25280, México.
  • Campos-Múzquiz LG; School of Chemistry, Universidad Autonoma de Coahuila, Saltillo, Coahuila, 25280, México.
  • Rodríguez-Herrera R; School of Chemistry, Universidad Autonoma de Coahuila, Saltillo, Coahuila, 25280, México.
Chem Biodivers ; 21(7): e202302065, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38768437
ABSTRACT
Grape pomace (GP), a by-product of wine production, contains bioactive polyphenols with potential health benefits. This study investigates the anti-inflammatory properties of a polyphenolic fraction derived from GP, obtained by ultrasound-microwave hybrid extraction and purified using ion-exchange chromatography. In the inflammation model, mice were divided into six groups intact, carrageenan, indomethacin, and three GP polyphenols treatment groups. Paw edema was induced by subplantar injection of carrageenan, and the GP polyphenols were administered intraperitoneally at doses of 10, 20, and 40 mg/kg. The anti-inflammatory effect was evaluated by measuring paw volume, and expression of inflammatory markers cyclooxygenase-2 (COX-2), myeloperoxidase (MPO), and cytokines (IL-1ß and IL-6), along with lipid peroxidation levels. The GP polyphenols significantly reduced paw edema and expression levels of COX-2, MPO, and cytokines in a dose-dependent manner effect, with the highest dose showing the greatest reduction. Additionally, lipid peroxidation levels were also decreased by GP polyphenols treatment at doses of 10 and 20 mg/kg. These findings suggest that ultrasound-microwave extraction combined with amberlite purification proved to be effective in obtaining a polyphenolic-rich fraction from GP. Thus, GP polyphenols may serve as a natural anti-inflammatory and antioxidant agent for treating inflammation and oxidative stress-related diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carragenina / Vitis / Modelos Animales de Enfermedad / Edema / Polifenoles / Inflamación Límite: Animals Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2024 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carragenina / Vitis / Modelos Animales de Enfermedad / Edema / Polifenoles / Inflamación Límite: Animals Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2024 Tipo del documento: Article Pais de publicación: Suiza