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Silver-Promoted Rapid Synthesis of 3-Arylindan-1-ones: Microwave-Assisted Reductive Coupling of N-Tosylhydrazone and Boronic Acids.
Tamizharasan, Natarajan; Santhoshkumar, Pandeeswaran; Devarajan, Nainamalai; Hallur, Mahanandeesha S; Hallur, Gurulingappa; Suresh, Palaniswamy.
Afiliación
  • Tamizharasan N; Supramolecular and Catalysis Lab, Department of Natural Products Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, Tamil Nadu 625021, India.
  • Santhoshkumar P; Medicinal Chemistry Department, Jubilant Biosys Ltd., Bangalore, Karnataka 560022, India.
  • Devarajan N; Supramolecular and Catalysis Lab, Department of Natural Products Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, Tamil Nadu 625021, India.
  • Hallur MS; Supramolecular and Catalysis Lab, Department of Natural Products Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, Tamil Nadu 625021, India.
  • Hallur G; Medicinal Chemistry Department, Jubilant Biosys Ltd., Bangalore, Karnataka 560022, India.
  • Suresh P; Medicinal Chemistry Department, Jubilant Biosys Ltd., Bangalore, Karnataka 560022, India.
J Org Chem ; 89(11): 7417-7428, 2024 Jun 07.
Article en En | MEDLINE | ID: mdl-38768212
ABSTRACT
An efficient and straightforward one-pot tandem synthesis of 3-arylindan-1-ones was consummated through silver nitrate-promoted C-C coupling of simple indane-1,3-dione with arylboronic acid via 1,3-indanedione monotosylhydrazone under microwave conditions. The resulting series of 3-arylindan-1-ones exhibited impressive yields, surpassing those achievable with traditional methods and requiring a shorter time frame. This innovative approach significantly accelerated the synthesis of biologically active compounds such as (+)-indatraline (Lu 19-005) and several other industrially relevant substances.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Org Chem Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Org Chem Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos