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MP-3 microperimeter in early primary open angle glaucoma with a new pattern.
Liang, Shuang; Wang, Li-Tao; Liu, Xiao-Li; Duan, Jia-Liang; Liu, Dan-Yan.
Afiliación
  • Liang S; Department of Ophthalmology of the Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China.
  • Wang LT; Department of Ophthalmology, Shijiazhuang People's Hospital, Shijiazhuang 050000, Hebei Province, China.
  • Liu XL; Department of Ophthalmology of the Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China.
  • Duan JL; Department of Ophthalmology of the Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China.
  • Liu DY; Department of Ophthalmology of the Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China.
Int J Ophthalmol ; 17(5): 861-868, 2024.
Article en En | MEDLINE | ID: mdl-38766350
ABSTRACT

AIM:

To investigate macular microperimetry in patients with early primary open angle glaucoma (POAG) using a new custom-made pattern, and analyze the characteristics of macular sensitivity.

METHODS:

This case-control study included 38 patients with POAG, who were divided into pre-perimetric glaucoma (18 eyes of 18 patients), early-stage (20 eyes of 20 patients), and control (20 eyes of 20 patients) groups. All subjects underwent standard 24-2 humphrey visual field test. An MP-3 microperimeter with a new custom-made pattern (28 testing points distributed in four quadrants, covering the central 10° of the retina) was used to evaluate macular sensitivity. Ganglion cell complex (GCC) thicknesses were examined using an RS-3000 Advance OCT system. The features of structure and function were analysed per quadrant.

RESULTS:

The pre-perimetric glaucoma group had significantly lower inferior hemifield macular sensitivity compared to controls (P<0.05). The early-stage POAG group had significantly lower average, inferior hemifield, inferonasal, and inferotemporal mean sensitivities compared to the pre-perimetric glaucoma group (P<0.05), and lower macular sensitivity in all sectors compared to controls (P<0.05). Regarding GCC thickness, all sectors in the early-stage POAG group became thinner compared to those in controls (P<0.05); whereas all sectors in the early-stage POAG group, except the superonasal quadrant, became thinner compared to those in the pre-perimetric glaucoma group (P<0.05). Macular sensitivity and GCC thickness were significantly associated in each sector. The inferotemporal quadrant had the highest correlation coefficients (0.840). The structure-function relationship for the inferonasal and inferotemporal sectors was stronger compared to the corresponding superior sectors.

CONCLUSION:

Microperimetry reveals variations in macular sensitivity in patients with early glaucoma earlier than conventional perimetry, particularly in pre-perimetric glaucoma cases in which it might be undetectable by conventional methods. The new custom-made pattern may improve the accuracy of microperimetry by enhancing point arrangement and reducing fatigue effects. Macular sensitivity measured by MP-3 with this pattern shows statistically significant structural and functional associations with the thicknesses of the GCC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Ophthalmol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Ophthalmol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: China