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Clinical observation on treatment of Alzheimer's disease with Sun's scalp-abdominal acupuncture combined with donepezil hydrochloride. / 孙氏头针腹针联合盐酸多奈哌齐治疗阿尔茨海默病的临床观察.
Zhang, Si-Qi; Ma, Shuai; Yang, Tian-Song; Zhang, Miao.
Afiliación
  • Zhang SQ; Graduate School of Heilongjiang University of Chinese Medicine, Harbin 150040, China.
  • Ma S; Graduate School of Heilongjiang University of Chinese Medicine, Harbin 150040, China.
  • Yang TS; The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040.
  • Zhang M; The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150001. 13845088833@139.com.
Zhen Ci Yan Jiu ; 49(5): 506-511, 2024 May 25.
Article en En, Zh | MEDLINE | ID: mdl-38764122
ABSTRACT

OBJECTIVES:

To observe the effect of scalp-abdominal acupuncture combined with donepezil hydrochloride on cognition and life ability of patients with Alzheimer's disease (AD), so as to evaluate its clinical efficacy.

METHODS:

Sixty AD patients were collected and randomly divided into control group (30 cases) and observation group (30 cases). Patients in the control group were treated with oral donepezil hydrochloride (5 mg, once daily). Patients in the observation group were treated with scalp-abdominal acupuncture at Baihui (GV20), Yintang (GV24+), Sishencong (EX-HN1), "emotional area", Shenting (GV24), "abdominal area 1""abdominal area 8", and bilateral Fengchi (GB20), Taixi (KI3), Xuanzhong (GB39), Zusanli (ST36) on the basis of control group, and electroacupuncture (10 Hz/50 Hz, 0.5 to 5.0 mA) was applied to EX-HN1, "emotional area""abdominal area 1" and "abdominal area 8", once daily, 30 min each time. Four weeks as a course of treatment, both the two groups were treated for two consecutive courses. Before and after treatment, the mini-mental state examination (MMSE), AD assessmennt scale-cognitive subscale (ADAS-Cog) and activity of daily living scale (ADL) were evaluated. The clinical efficacy index was calculated and safety was evaluated.

RESULTS:

After treatment, the MMSE and ADL scores were higher (P<0.05) and the ADAS-Cog score was lower (P<0.05) than those before treatment in both groups. Compared with the control group, the MMSE and ADL scores were increased (P<0.05) and ADAS-Cog score was decreased (P<0.05) in the observation group. The total effective rate of the observation group (26/30, 86.67%) was higher (P<0.05) than that of the control group (23/30, 76.67%). No adverse reactions occurred in both groups during the treatment.

CONCLUSIONS:

Scalp-abdominal acupuncture combined with donepezil hydrochloride can effectively improve the cognitive ability and daily living ability of AD patients, and the efficacy is better than that of oral donepezil hydrochloride alone.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cuero Cabelludo / Puntos de Acupuntura / Terapia por Acupuntura / Enfermedad de Alzheimer / Donepezilo Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En / Zh Revista: Zhen Ci Yan Jiu Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cuero Cabelludo / Puntos de Acupuntura / Terapia por Acupuntura / Enfermedad de Alzheimer / Donepezilo Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En / Zh Revista: Zhen Ci Yan Jiu Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: China