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Synthesis of selenophene-containing flavonols and 2-styrylchromones: Evaluation of their activities compared with selenophene-containing chalcones as potential anticancer agents.
Chen, Ya-Chen; Chang, Chuan-Hsin; Tang, Mei-Hsin; Ding, Yu Chun; Wu, I-Ching; Ye, Wei-Tong; Shih, Tzenge-Lien.
Afiliación
  • Chen YC; Department of Chemistry, Tamkang University, Tamsui District, New Taipei City, Taiwan.
  • Chang CH; Research Center for Chinese Herbal Medicine, Graduate Institute of Healthy Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan.
  • Tang MH; Department of Chemistry, Tamkang University, Tamsui District, New Taipei City, Taiwan.
  • Ding YC; Department of Chemistry, Tamkang University, Tamsui District, New Taipei City, Taiwan.
  • Wu IC; Department of Nutrition and Health Science, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan.
  • Ye WT; Department of Nutrition and Health Science, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan.
  • Shih TL; Department of Chemistry, Tamkang University, Tamsui District, New Taipei City, Taiwan.
Arch Pharm (Weinheim) ; 357(9): e2400242, 2024 Sep.
Article en En | MEDLINE | ID: mdl-38763904
ABSTRACT
Previously, we documented the synthesis and assessed the biological effects of chalcones containing selenium against HT-29 human colorectal adenocarcinoma cells, demonstrating their significant potential. As research on selenium-containing flavonoids remains limited, this article outlines our design and synthesis of three selenium-based flavonols and three 2-styrylchromones. We conducted evaluations of these compounds to determine their impact on human lung cancer cells (A549, H1975, CL1-0, and CL1-5) and their influence on normal lung fibroblast MRC5 cells. Additionally, we included selenium-based chalcones in our testing for comparative purposes. Our findings highlight that the simplest compound, designated as compound 1, exhibited the most promising performance among the tested molecules.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Flavonoles / Chalconas / Antineoplásicos Límite: Humans Idioma: En Revista: Arch Pharm (Weinheim) Año: 2024 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Alemania
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Flavonoles / Chalconas / Antineoplásicos Límite: Humans Idioma: En Revista: Arch Pharm (Weinheim) Año: 2024 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Alemania