Impact on survival without chemotherapy of local treatments of lung metastasis of colorectal cancers: Analysis on REPULCO cohort.
Dig Liver Dis
; 56(11): 1930-1937, 2024 Nov.
Article
en En
| MEDLINE
| ID: mdl-38763795
ABSTRACT
BACKGROUND:
The impact of local management of pulmonary metastases on the disease course of patients with metastatic colorectal cancer is poorly assessed.METHODS:
REPULCO database was a retrospective cohort on 18 years that included all patients treated for lung metastases from colorectal cancer who received local and/or systemic treatments.AIMS:
Primary objective was overall survival, secondary were progression-free survival and survival without chemotherapy.RESULTS:
Three hundred and fifteen patients were analyzed, 157 with only systemic treatments, 78 with only local treatments, and 80 with local and systemic treatments. Overall survival at 5 years was 26.9% (IC95% [17.7-36.9]) for systemic treatments only, 61.0% (IC95% [40.8-76.1]) for local treatments only, and 77.8% (IC95% [60.1-88.3]) for local and systemic treatments. Progression-free survival at 2 years was 4.8% (IC95% [2.1-9.2]) for systemic treatment only, 28.3% (IC95% [17.7-39.9]) for local treatments only, and 21.8% (IC95% [13.1-31.9]) for local and systemic treatments. Median survival without chemotherapy was 2.99 months (IC95% [2.33-3.68]) for systemic treatments, 33.97 months (IC95% [19.06-NA]) for local treatments, and 12.85 months (IC95% [8.18-21.06]) for local and systemic treatments.CONCLUSION:
Local treatments of lung metastasis led to prolonged survival and allowed long periods of time without chemotherapy in this cohort.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Colorrectales
/
Neoplasias Pulmonares
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
País/Región como asunto:
Europa
Idioma:
En
Revista:
Dig Liver Dis
Asunto de la revista:
GASTROENTEROLOGIA
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Países Bajos