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Comparative Data of Procedural and Midterm Outcomes in Patients Who Underwent Percutaneous Left Atrial Appendage Closure Between the WATCHMAN FLX and WATCHMAN 2.5 Devices　- Insight From the OCEAN-LAAC Registry.
Nakashima, Masaki; Yamamoto, Masanori; Sago, Mitsuru; Tanaka, Shuhei; Chatani, Ryuki; Asami, Masahiko; Hachinohe, Daisuke; Naganuma, Toru; Ohno, Yohei; Tani, Tomoyuki; Okamatsu, Hideharu; Mizutani, Kazuki; Watanabe, Yusuke; Izumo, Masaki; Saji, Mike; Mizuno, Shingo; Ueno, Hiroshi; Kubo, Shunsuke; Shirai, Shinichi; Hayashida, Kentaro.
Afiliación
  • Nakashima M; Department of Cardiology, Sendai Kousei Hospital.
  • Yamamoto M; Department of Cardiology, Toyohashi Heart Center.
  • Sago M; Department of Cardiology, Nagoya Heart Center.
  • Tanaka S; Department of Cardiology, Gifu Heart Center.
  • Chatani R; Department of Cardiology, Toyohashi Heart Center.
  • Asami M; Department of Cardiology, Toyama University Hospital.
  • Hachinohe D; Department of Cardiology, Kurashiki Central Hospital.
  • Naganuma T; Division of Cardiology, Mitsui Memorial Hospital.
  • Ohno Y; Department of Cardiology, Sapporo Heart Center, Sapporo Cardio Vascular Clinic.
  • Tani T; Department of Cardiology, New Tokyo Hospital.
  • Okamatsu H; Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University.
  • Mizutani K; Department of Cardiology, Tokai University School of Medicine.
  • Watanabe Y; Department of Cardiology, Sapporo East Tokushukai Hospital.
  • Izumo M; Department of Cardiology, Saiseikai Kumamoto Hospital.
  • Saji M; Division of Cardiology, Department of Medicine, Kindai University Faculty of Medicine.
  • Mizuno S; Department of Cardiology, Teikyo University School of Medicine.
  • Ueno H; Department of Cardiology, St. Marianna University School of Medicine.
  • Kubo S; Department of Cardiology, Sakakibara Heart Institute.
  • Shirai S; Department of Cardiology, Shonan Kamakura General Hospital.
  • Hayashida K; Department of Cardiology, Toyama University Hospital.
Circ J ; 88(7): 1187-1197, 2024 06 25.
Article en En | MEDLINE | ID: mdl-38763735
ABSTRACT

BACKGROUND:

Limited data are available regarding clinical outcomes after percutaneous left atrial appendage closure using WATCHMAN FLX (WM-FLX) and WATCHMAN-2.5 (WM2.5) devices in Asian patients. METHODS AND 

RESULTS:

Data of 1,464 consecutive patients (WM-FLX, n=909; WM2.5, n=555) were extracted from a Japanese multicenter registry, and clinical data were compared between the 2 groups. No in-hospital deaths, periprocedural stroke, or device embolization occurred. Procedural success was significantly higher in the WM-FLX than WM2.5 group (95.8% vs. 91.9%; P=0.002) owing to the lower incidence of periprocedural pericardial effusion (0.55% vs. 1.8%; P=0.021). No significant differences in all-cause death, postprocedural stroke, and device-related thrombus were observed between the 2 groups. However, the cumulative bleeding rate at 1 year was substantially lower in the WM-FLX group (7.8% vs. 16.4%; P<0.001). Landmark analysis of bleeding events highlighted lower bleeding rates in the WM-FLX than WM2.5 group within the first 6 months (6.4% vs. 14.8%; P<0.001), with comparable bleeding rates over the 6- to 12-month period (1.5% vs. 3.2%, respectively; P=0.065).

CONCLUSIONS:

This study demonstrated higher early safety and lower 1-year bleeding rates in the WM-FLX than WM2.5 group. The lower bleeding events with WM-FLX are likely due to multiple factors other than purely difference in devices, such as postprocedural drug regimen.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fibrilación Atrial / Sistema de Registros / Apéndice Atrial Límite: Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Circ J Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Japón
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fibrilación Atrial / Sistema de Registros / Apéndice Atrial Límite: Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Circ J Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Japón