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eHealth mindfulness-based music therapy for patients undergoing allogeneic hematopoietic stem cell transplantation: A pilot randomized controlled trial protocol.
Fleszar-Pavlovic, Sara E; Esquives, Blanca Noriega; Brito, Arianna E; Sia, Ann Marie; Kauffman, Mary Adelyn; Lopes, Maria; Moreno, Patricia I; Koru-Sengul, Tulay; Gong, Rui; Wang, Trent; Wieder, Eric D; Rueda-Lara, Maria; Antoni, Michael; Komanduri, Krishna; Lesiuk, Teresa; Penedo, Frank J.
Afiliación
  • Fleszar-Pavlovic SE; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address: sef144@med.miami.edu.
  • Esquives BN; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address: bsn24@miami.edu.
  • Brito AE; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address: aeb178@med.miami.edu.
  • Sia AM; Department of Undergraduate Research, University of Miami, Coral Gables, FL, USA. Electronic address: ams934@miami.edu.
  • Kauffman MA; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address: m.kauffman@miami.edu.
  • Lopes M; Department of Psychology, College of Arts and Sciences, University of Miami, Coral Gables, FL, USA. Electronic address: mxl1187@miami.edu.
  • Moreno PI; Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address: patricia.moreno@miami.edu.
  • Koru-Sengul T; Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address: tsengul@med.miami.edu.
  • Gong R; Department of Medicine and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address: rxg1321@miami.edu.
  • Wang T; Department of Medicine and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address: trentwang@med.miami.edu.
  • Wieder ED; Department of Medicine and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address: ewieder@med.miami.edu.
  • Rueda-Lara M; Department of Psychiatry and Behavioral Sciences and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address: mrueda2@med.miami.edu.
  • Antoni M; Department of Psychology and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address: mantoni@miami.edu.
  • Komanduri K; Department of Medicine, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA. Electronic address: Krishna.Komanduri@ucsf.edu.
  • Lesiuk T; Frost School of Music and Sylvester Comprehensive Cancer Center, University of Miami, Coral Gables, FL, USA. Electronic address: tlesiuk@miami.edu.
  • Penedo FJ; Departments of Psychology and Medicine, and Sylvester Comprehensive Cancer Center, University of Miami, Coral Gables, FL, USA. Electronic address: frank.penedo@miami.edu.
Contemp Clin Trials ; 142: 107577, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38763308
ABSTRACT

BACKGROUND:

Allogeneic stem cell transplantation (allo-SCT) is the preferred therapy for patients with high-risk or relapsed hematologic malignancies, but may be complicated by psychological distress (e.g., depression, anxiety) and symptom burden (e.g., fatigue, pain). Mindfulness-based music therapy (MBMT), a relatively novel integrative medicine intervention that draws from mindfulness and music therapy principles, has shown promise in improving psychosocial outcomes and symptom burden in cancer patients. We outline an eHealth-based MBMT (eMBMT) intervention protocol examining (1) feasibility, acceptability, and intended effects of eMBMT in improving HRQOL, symptom burden, and clinical markers of disease activity (e.g., infections), and (2) the extent to which eMBMT music therapy component-associated improvements in HRQOL, symptom burden, and disease activity are mediated by improvements in psychosocial and physiological (e.g., systemic inflammation, immune recovery) adaptation.

METHODS:

Participants (n = 60) with a hematologic malignancy undergoing allo-SCT will be randomized to receive eMBMT or an eHealth-based mindfulness meditation (eMM) intervention. eMBMT includes eight 60-min sessions facilitated by a music therapist focusing on mindfulness and music therapy. eMM includes eight 60-min self-led MM practices.

RESULTS:

Feasibility, acceptability, HRQOL, symptom burden, disease activity, and mediation effects of psychosocial and physiological adaptation will be assessed at baseline, pre-infusion, and post-engraftment with blood collection at baseline and post-engraftment.

CONCLUSION:

The current pilot RCT is the first eMBMT intervention to address the HRQOL and symptom burden of patients who are undergoing allo-SCT. Results will inform a fully powered RCT to establish preliminary efficacy of eMBMT on improvements in HRQOL, symptom burden, and disease activity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Calidad de Vida / Trasplante de Células Madre Hematopoyéticas / Neoplasias Hematológicas / Atención Plena / Musicoterapia Límite: Adult / Female / Humans / Male Idioma: En Revista: Contemp Clin Trials Asunto de la revista: MEDICINA / TERAPEUTICA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Calidad de Vida / Trasplante de Células Madre Hematopoyéticas / Neoplasias Hematológicas / Atención Plena / Musicoterapia Límite: Adult / Female / Humans / Male Idioma: En Revista: Contemp Clin Trials Asunto de la revista: MEDICINA / TERAPEUTICA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos