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T Cell Exhaustion Markers in Multiple Myeloma Patients are Lower After Physical Activity Intervention.
Joseph, Janine M; Hillengass, Michaela; Cannioto, Rikki; Tario, Joseph D; Wallace, Paul K; Attwood, Kristopher; Groman, Adrienne; Jacobson, Hillary; Wittmeyer, Bryan; Mohammadpour, Hemn; Abrams, Scott I; Moysich, Kirsten B; Hillengass, Jens.
Afiliación
  • Joseph JM; Roswell Park Comprehensive Cancer Center, Department of Cancer Prevention and Control, Buffalo, NY. Electronic address: janine.joseph@roswellpark.org.
  • Hillengass M; Roswell Park Comprehensive Cancer Center, Department of Cancer Prevention and Control, Buffalo, NY.
  • Cannioto R; Roswell Park Comprehensive Cancer Center, Department of Cancer Prevention and Control, Buffalo, NY.
  • Tario JD; Roswell Park Comprehensive Cancer Center, Department of Flow Cytometry Laboratory (Clinical), Buffalo, NY.
  • Wallace PK; Roswell Park Comprehensive Cancer Center, Department of Cell Stress Biology, Buffalo, NY.
  • Attwood K; Roswell Park Comprehensive Cancer Center, Department of Biostatistics and Bioinformatics, Buffalo, NY.
  • Groman A; Roswell Park Comprehensive Cancer Center, Department of Biostatistics and Bioinformatics, Buffalo, NY.
  • Jacobson H; Roswell Park Comprehensive Cancer Center, Department of Physical Therapy, Buffalo, NY.
  • Wittmeyer B; Roswell Park Comprehensive Cancer Center, Department of Physical Therapy, Buffalo, NY.
  • Mohammadpour H; Roswell Park Comprehensive Cancer Center, Department of Cell Stress Biology, Buffalo, NY.
  • Abrams SI; Roswell Park Comprehensive Cancer Center, Department of Immunology, Buffalo, NY.
  • Moysich KB; Roswell Park Comprehensive Cancer Center, Department of Cancer Prevention and Control, Buffalo, NY.
  • Hillengass J; Roswell Park Comprehensive Cancer Center, Department of Medicine - Myeloma, Buffalo, NY.
Clin Lymphoma Myeloma Leuk ; 24(9): 621-628, 2024 Sep.
Article en En | MEDLINE | ID: mdl-38762420
ABSTRACT

PURPOSE:

There is compelling evidence that CD4+ and CD8+T cells are dysfunctional in multiple myeloma, compromising their ability to control disease progression. Pre-clinical models suggest that exercise represents a non-pharmacologic means to reduce immune exhaustion, but no studies to date have examined the relationship between an exercise intervention and biomarkers of immune exhaustion in multiple myeloma patients. PATIENTS AND

METHODS:

The current study includes 24 multiple myeloma patients who participated in a six-month physical activity intervention, consisting of supervised strength training (n = 12) and unsupervised home-based walking arms (n = 12). Comprehensive flow cytometry was utilized to assess the frequency of CD4+ and CD8+T cells and subpopulations expressing the markers of exhaustion PD-1, TIGIT, TIM3 and/or LAG3. Ratios of exhausted to non-exhausted cell populations, and percentages of exhausted to total populations of the same lineage, were calculated for the baseline and final timepoints.

RESULTS:

Eighteen of 20 exhaustion measures were lower at the end of the intervention than at baseline, and several were significantly or borderline significantly reduced in the entire sample or in one of the arms. The entire sample saw improvements in the ratios of CD4+ TIGIT+ to non-exhausted CD4+ (0.7 [0.6] to 0.6 [0.4], P = .04) and CD8+ PD1+ to non-exhausted CD8+ (1.8 [2.6] to 1.5 [2.0], P = .06), and in total exhausted CD8+ as a percent of total CD8+ (72.9 [21.9] to 68.3 [19.6], P < .01).

CONCLUSIONS:

This pilot study suggests that physical activity induces changes in MM patients' immune systems, potentially rendering a less exhausted T cell state.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ejercicio Físico / Linfocitos T CD8-positivos / Mieloma Múltiple Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Lymphoma Myeloma Leuk Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ejercicio Físico / Linfocitos T CD8-positivos / Mieloma Múltiple Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Lymphoma Myeloma Leuk Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos