Your browser doesn't support javascript.
loading
Peripheral serotonin levels as a predictor of antidepressant treatment response: A systematic review.
Holck, Amanda; Movahed, Pouya; Westrin, Åsa; Wolkowitz, Owen M; Lindqvist, Daniel; Asp, Marie.
Afiliación
  • Holck A; Unit for Biological and Precision Psychiatry, Department of Clinical Sciences Lund, Lund University, Lund, Sweden; Psychiatric Clinic Lund, Lund, Sweden. Electronic address: amanda.holck@med.lu.se.
  • Movahed P; Psychiatric Clinic Lund, Lund, Sweden; Psychiatric Neuromodulation Unit, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
  • Westrin Å; Unit for Clinical Suicide Research, Department of Clinical Sciences Lund, Lund University, Lund, Sweden; The Region Skåne Committee on Psychiatry, Habilitation and Technical Aids, Sweden.
  • Wolkowitz OM; Department of Psychiatry and Behavioral Sciences and Weill Institute for Neurosciences, University of California, San Francisco, School of Medicine, San Francisco, CA, USA.
  • Lindqvist D; Unit for Biological and Precision Psychiatry, Department of Clinical Sciences Lund, Lund University, Lund, Sweden; Office for Psychiatry, Habilitation and Technical Aids, Psychiatry Research Skåne, Region Skåne, Lund, Sweden.
  • Asp M; Unit for Biological and Precision Psychiatry, Department of Clinical Sciences Lund, Lund University, Lund, Sweden; Psychiatric Clinic Lund, Lund, Sweden.
Prog Neuropsychopharmacol Biol Psychiatry ; 133: 111031, 2024 Jul 13.
Article en En | MEDLINE | ID: mdl-38762162
ABSTRACT
There are currently no reliable biomarkers to predict clinical response to pharmacological treatments of depressive disorders. Peripheral blood 5-hydroxytryptamine (5-HT; serotonin) has been suggested as a biomarker of antidepressant treatment response, but there has not been an attempt to systematically summarize and evaluate the scientific evidence of this hypothesis. In this systematic review we searched MEDLINE, Embase, PsycINFO, and the Cochrane Central Register of Controlled Trials. Twenty-six relevant studies investigating peripheral 5-HT as an antidepressant biomarker were identified. In all, we did not find robust support for an association between baseline 5-HT and treatment response. Several larger studies with lower risk of bias, however, showed that higher baseline 5-HT was associated with a greater antidepressant response to SSRIs, prompting future studies to investigate this hypothesis. Our results also confirm previous reports that SSRI treatment is associated with a decrease in peripheral 5-HT levels; however, we were not able to confirm that larger decreases of 5-HT are associated with better treatment outcome as results were inconclusive.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Serotonina / Antidepresivos Límite: Humans Idioma: En Revista: Prog Neuropsychopharmacol Biol Psychiatry Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Serotonina / Antidepresivos Límite: Humans Idioma: En Revista: Prog Neuropsychopharmacol Biol Psychiatry Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido