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Interior decorative volatile organic compounds exposure induces sleep disorders through aberrant branched chain amino acid transaminase 2 mediated glutamatergic signaling resulting from a neuroinflammatory cascade.
Zheng, Jie; Wu, Mengqi; Pang, Yaxian; Liu, Qingping; Liu, Yan; Jin, Xiaoting; Tang, Jinglong; Bao, Lei; Niu, Yujie; Zheng, Yuxin; Zhang, Rong.
Afiliación
  • Zheng J; Department of Toxicology, School of Public Health, Hebei Medical University, Shijiazhuang 050017, Hebei, PR China; Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei, PR China.
  • Wu M; Department of Toxicology, School of Public Health, Hebei Medical University, Shijiazhuang 050017, Hebei, PR China.
  • Pang Y; Department of Toxicology, School of Public Health, Hebei Medical University, Shijiazhuang 050017, Hebei, PR China.
  • Liu Q; Department of Toxicology, School of Public Health, Hebei Medical University, Shijiazhuang 050017, Hebei, PR China.
  • Liu Y; Department of Toxicology, School of Public Health, Hebei Medical University, Shijiazhuang 050017, Hebei, PR China; School of Public Health, Inner Mongolia Medical University, Hohhot 010000, Inner Mongolia, PR China.
  • Jin X; Department of Occupational and Environmental Health, School of Public Health, Qingdao University, Qingdao 266071, Shandong, PR China.
  • Tang J; Department of Occupational and Environmental Health, School of Public Health, Qingdao University, Qingdao 266071, Shandong, PR China.
  • Bao L; Department of Occupational Health and Environmental Health, Hebei Medical University, Shijiazhuang 050017, Hebei, PR China.
  • Niu Y; Department of Occupational Health and Environmental Health, Hebei Medical University, Shijiazhuang 050017, Hebei, PR China; Hebei Key Laboratory of Environment and Human Health, Hebei Medical University, Shijiazhuang 050017, Hebei, PR China.
  • Zheng Y; Department of Occupational and Environmental Health, School of Public Health, Qingdao University, Qingdao 266071, Shandong, PR China. Electronic address: yxzheng@qdu.edu.cn.
  • Zhang R; Department of Toxicology, School of Public Health, Hebei Medical University, Shijiazhuang 050017, Hebei, PR China; Hebei Key Laboratory of Environment and Human Health, Hebei Medical University, Shijiazhuang 050017, Hebei, PR China. Electronic address: rongzhang@hebmu.edu.cn.
Sci Total Environ ; 934: 173254, 2024 Jul 15.
Article en En | MEDLINE | ID: mdl-38761924
ABSTRACT
Air pollution has been recognized as a contributing factor to sleep disorders (SD), which have been correlated with an elevated susceptibility to a variety of human diseases. Nevertheless, research has not definitively established a connection between SD and interior decorative volatile organic compounds (ID-VOCs), a significant indoor air pollutant. In this study, we employed a mouse model exposed to ID-VOCs to explore the impacts of ID-VOCs exposure on sleep patterns and the potential underlying mechanism. Of the 23 key compositions of ID-VOCs identified, aromatic hydrocarbons were found to be the most prevalent. Exposure to ID-VOCs in mice resulted in SD, characterized by prolonged wake fullness and decreased sleep during the light period. ID-VOCs exposure triggered neuroinflammatory responses in the suprachiasmatic nucleus (SCN), with microglia activation leading to the overproduction of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1α (IL-1α), and complement component 1q (C1q), ultimately inducing A1 astrocytes. Consequently, the upregulation of branched chain amino acid transaminase 2 (BCAT2) in A1 astrocytes resulted in elevated extracellular glutamate and disruption of the wake-sleep transition mechanism, which might be the toxicological mechanism of SD caused by ID-VOCs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos del Sueño-Vigilia / Contaminantes Atmosféricos / Compuestos Orgánicos Volátiles Límite: Animals Idioma: En Revista: Sci Total Environ Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos del Sueño-Vigilia / Contaminantes Atmosféricos / Compuestos Orgánicos Volátiles Límite: Animals Idioma: En Revista: Sci Total Environ Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos