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Polyphosphoester-stabilized cubosomes encapsulating a Ru(II) complex for the photodynamic treatment of lung adenocarcinoma.
Casula, Luca; Elena Giacomazzo, Gina; Conti, Luca; Fornasier, Marco; Manca, Benedetto; Schlich, Michele; Sinico, Chiara; Rheinberger, Timo; Wurm, Frederik R; Giorgi, Claudia; Murgia, Sergio.
Afiliación
  • Casula L; Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria Monserrato, S.P. 8 Km 0.700, 09042 Monserrato, CA, Italy.
  • Elena Giacomazzo G; Department of Chemistry "Ugo Schiff", University of Florence, via della Lastruccia 3, 50019 Sesto Fiorentino, FI, Italy.
  • Conti L; Department of Chemistry "Ugo Schiff", University of Florence, via della Lastruccia 3, 50019 Sesto Fiorentino, FI, Italy.
  • Fornasier M; Department of Chemistry, Lund University, SE-22100 Lund, Sweden; CSGI, Consorzio Interuniversitario per lo Sviluppo dei Sistemi a Grande Interfase, 50019 Sesto Fiorentino, FI, Italy.
  • Manca B; Department of Mathematics and Computer Science, University of Cagliari, via Ospedale 72, 09124 Cagliari, CA, Italy.
  • Schlich M; Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria Monserrato, S.P. 8 Km 0.700, 09042 Monserrato, CA, Italy.
  • Sinico C; Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria Monserrato, S.P. 8 Km 0.700, 09042 Monserrato, CA, Italy.
  • Rheinberger T; Sustainable Polymer Chemistry (SPC), Department of Molecules and Materials, MESA+ Institute for Nanotechnology, Faculty of Science and Technology, University of Twente, P.O. Box 217, Enschede 7500 AE, Netherlands.
  • Wurm FR; Sustainable Polymer Chemistry (SPC), Department of Molecules and Materials, MESA+ Institute for Nanotechnology, Faculty of Science and Technology, University of Twente, P.O. Box 217, Enschede 7500 AE, Netherlands.
  • Giorgi C; Department of Chemistry "Ugo Schiff", University of Florence, via della Lastruccia 3, 50019 Sesto Fiorentino, FI, Italy.
  • Murgia S; Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria Monserrato, S.P. 8 Km 0.700, 09042 Monserrato, CA, Italy; CSGI, Consorzio Interuniversitario per lo Sviluppo dei Sistemi a Grande Interfase, 50019 Sesto Fiorentino, FI, Italy. Electronic address: murgias@
J Colloid Interface Sci ; 670: 234-245, 2024 Sep 15.
Article en En | MEDLINE | ID: mdl-38761576
ABSTRACT
The clinical translation of photosensitizers based on ruthenium(II) polypyridyl complexes (RPCs) in photodynamic therapy of cancer faces several challenges. To address these limitations, we conducted an investigation to assess the potential of a cubosome formulation stabilized in water against coalescence utilizing a polyphosphoester analog of Pluronic F127 as a stabilizer and loaded with newly synthesized RPC-based photosensitizer [Ru(dppn)2(bpy-morph)](PF6)2 (bpy-morph = 2,2'-bipyridine-4,4'-diylbis(morpholinomethanone)), PS-Ru. The photophysical characterization of PS-Ru revealed its robust capacity to induce the formation of singlet oxygen (1O2). Furthermore, the physicochemical analysis of the PS-Ru-loaded cubosomes dispersion demonstrated that the encapsulation of the photosensitizer within the nanoparticles did not disrupt the three-dimensional arrangement of the lipid bilayer. The biological tests showed that PS-Ru-loaded cubosomes exhibited significant phototoxic activity when exposed to the light source, in stark contrast to empty cubosomes and to the same formulation without irradiation. This promising outcome suggests the potential of the formulation in overcoming the drawbacks associated with the clinical use of RPCs in photodynamic therapy for anticancer treatments.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fotoquimioterapia / Rutenio / Fármacos Fotosensibilizantes / Neoplasias Pulmonares Límite: Humans Idioma: En Revista: J Colloid Interface Sci Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fotoquimioterapia / Rutenio / Fármacos Fotosensibilizantes / Neoplasias Pulmonares Límite: Humans Idioma: En Revista: J Colloid Interface Sci Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos