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Hemodynamics and wall shear metrics in a pulmonary autograft: Comparing a fluid-structure interaction and computational fluid dynamics approach.
Balasubramanya, Amith; Maes, Lauranne; Rega, Filip; Mazzi, Valentina; Morbiducci, Umberto; Famaey, Nele; Degroote, Joris; Segers, Patrick.
Afiliación
  • Balasubramanya A; IBiTech-BioMMedA, Ghent University, Ghent, Belgium. Electronic address: amith.balusubramanya@ugent.be.
  • Maes L; Department of Mechanical Engineering, KU Leuven, Leuven, Belgium.
  • Rega F; Cardiac Surgery, Department of Cardiovascular Sciences, KU Leuven, Belgium.
  • Mazzi V; PolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy.
  • Morbiducci U; PolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy.
  • Famaey N; Department of Mechanical Engineering, KU Leuven, Leuven, Belgium.
  • Degroote J; Department of Electromechanical Systems and Metal Engineering, Ghent University, Ghent, Belgium.
  • Segers P; IBiTech-BioMMedA, Ghent University, Ghent, Belgium.
Comput Biol Med ; 176: 108604, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38761502
ABSTRACT

OBJECTIVE:

In young patients, aortic valve disease is often treated by placement of a pulmonary autograft (PA) which adapts to its new environment through growth and remodeling. To better understand the hemodynamic forces acting on the highly distensible PA in the acute phase after surgery, we developed a fluid-structure interaction (FSI) framework and comprehensively compared hemodynamics and wall shear-stress (WSS) metrics with a computational fluid dynamic (CFD) simulation.

METHODS:

The FSI framework couples a prestressed non-linear hyperelastic arterial tissue model with a fluid model using the in-house coupling code CoCoNuT. Geometry, material parameters and boundary conditions are based on in-vivo measurements. Hemodynamics, time-averaged WSS (TAWSS), oscillatory shear index (OSI) and topological shear variation index (TSVI) are evaluated qualitatively and quantitatively for 3 different sheeps.

RESULTS:

Despite systolic-to-diastolic volumetric changes of the PA in the order of 20 %, the point-by-point correlation of TAWSS and OSI obtained through CFD and FSI remains high (r > 0.9, p < 0.01) for TAWSS and (r > 0.8, p < 0.01) for OSI). Instantaneous WSS divergence patterns qualitatively preserve similarities, but large deformations of the PA leads to a decrease of the correlation between FSI and CFD resolved TSVI (r < 0.7, p < 0.01). Moderate co-localization between FSI and CFD is observed for low thresholds of TAWSS and high thresholds of OSI and TSVI.

CONCLUSION:

FSI might be warranted if we were to use the TSVI as a mechano-biological driver for growth and remodeling of PA due to varying intra-vascular flow structures and near wall hemodynamics because of the large expansion of the PA.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arteria Pulmonar / Hemodinámica / Modelos Cardiovasculares Límite: Animals / Humans Idioma: En Revista: Comput Biol Med Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arteria Pulmonar / Hemodinámica / Modelos Cardiovasculares Límite: Animals / Humans Idioma: En Revista: Comput Biol Med Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos