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Effects of fructooligosaccharides and Saccharomyces boulardii on the compositional structure and metabolism of gut microbiota in students.
Fu, Hao; Chen, Zhixian; Teng, Weilin; Du, Zhi; Zhang, Yan; Ye, Xiaoli; Yu, Zaichun; Zhang, Yinjun; Pi, Xionge.
Afiliación
  • Fu H; Institute of Plant Protection and Microbiology, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, PR China.
  • Chen Z; National Key Laboratory of Agricultural Microbiology, Angel Yeast Co., Ltd., Yichang 443003, PR China; The Hubei Provincial Key Laboratory of Yeast Function, Angel Yeast Co., Ltd., Yichang 443003, PR China; Yi Chang Engineering and Technology Research Center of Nutrition and Health Food, Angel Yeast
  • Teng W; Department of infectious Disease Control and Prevention, HangZhou Center for Disease Control and Prevention, Hangzhou 310006, PR China.
  • Du Z; Department of Pharmacy, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, PR China.
  • Zhang Y; National Key Laboratory of Agricultural Microbiology, Angel Yeast Co., Ltd., Yichang 443003, PR China; The Hubei Provincial Key Laboratory of Yeast Function, Angel Yeast Co., Ltd., Yichang 443003, PR China; Yi Chang Engineering and Technology Research Center of Nutrition and Health Food, Angel Yeast
  • Ye X; Department of Pharmacy, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, PR China.
  • Yu Z; College of Bioengineering, Zhejiang University of Technology, Hangzhou 310014, PR China.
  • Zhang Y; College of Bioengineering, Zhejiang University of Technology, Hangzhou 310014, PR China.
  • Pi X; Institute of Plant Protection and Microbiology, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, PR China; Institute of Rural Development, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, PR China. Electronic address: pixionge@163.com.
Microbiol Res ; 285: 127741, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38761487
ABSTRACT
Fructooligosaccharides (FOS) are a common prebiotic widely used in functional foods. Meanwhile, Saccharomyces boulardii is a fungal probiotic frequenly used in the clinical treatment of diarrhea. Compared with single use, the combination of prebiotics and probiotics as symbiotics may be more effective in regulating gut microbiota as recently reported in the literature. The present study aimed to investigate the effects of FOS, S. boulardii and their combination on the structure and metabolism of the gut microbiota in healthy primary and secondary school students using an in vitro fermentation model. The results indicated that S. boulardii alone could not effectively regulate the community structure and metabolism of the microbiota. However, both FOS and the combination of FOS and S. boulardii could effectively regulate the microbiota, significantly inhibiting the growth of Escherichia-Shigella and Bacteroides, and controlling the production of the gases including H2S and NH3. In addition, both FOS and the combination could significantly promote the growth of Bifidobacteria and Lactobacillus, lower environmental pH, and enhance several physiological functions related to synthesis and metabolism. Nevertheless, the combination had more unique benefits as it promoted the growth of Lactobacillus, significantly increased CO2 production and enhanced the functional pathways of carbon metabolism and pyruvic acid metabolism. These findings provide guidance for clinical application and a theoretical basis for the development of synbiotic preparations.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligosacáridos / Estudiantes / Probióticos / Prebióticos / Fermentación / Microbioma Gastrointestinal / Saccharomyces boulardii Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Microbiol Res Asunto de la revista: MICROBIOLOGIA / SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligosacáridos / Estudiantes / Probióticos / Prebióticos / Fermentación / Microbioma Gastrointestinal / Saccharomyces boulardii Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Microbiol Res Asunto de la revista: MICROBIOLOGIA / SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article Pais de publicación: Alemania