Cysteine substitutants emerge in lung cancer proteomes during arginine restriction.

Hsu, Dennis J; Tavazoie, Sohail F

Hsu, Dennis J; Tavazoie, Sohail F.

Afiliación

Hsu DJ; Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: djh138@pitt.edu.
Tavazoie SF; Laboratory of Systems Cancer Biology, The Rockefeller University, New York, NY, USA. Electronic address: stavazoie@rockefeller.edu.

Mol Cell ; 84(10): 1819-1821, 2024 May 16.

Article en En | MEDLINE | ID: mdl-38759621

ABSTRACT

ABSTRACT

In this issue of Molecular Cell, Yang et al.1 find that arginine-to-cysteine substitutants are enriched in a subset of lung cancer proteomes, potentiated by arginine deprivation, and promote resistance to chemotherapy.

Asunto(s)

Arginina; Cisteína; Neoplasias Pulmonares; Proteoma; Humanos; Cisteína/metabolismo; Neoplasias Pulmonares/metabolismo; Neoplasias Pulmonares/tratamiento farmacológico; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/patología; Arginina/metabolismo; Proteoma/metabolismo; Resistencia a Antineoplásicos/genética

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arginina / Proteoma / Cisteína / Neoplasias Pulmonares Límite: Humans Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos

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