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Change of hand sensation and function in patients with malignant lymphoma during early-stage vincristine chemotherapy: A single-center observational study.
Iokawa, Kazuaki; Fujita, Takaaki; Yoshida, Shizuka; Mogi, Yuka; Kasahara, Ryuichi; Yamamoto, Yuichi; Kai, Tatsuyuki.
Afiliación
  • Iokawa K; Department of Occupational Therapy, School of Health Sciences, Fukushima Medical University, Fukushima City, Fukushima, Japan.
  • Fujita T; Department of Occupational Therapy, School of Health Sciences, Fukushima Medical University, Fukushima City, Fukushima, Japan.
  • Yoshida S; Department of Rehabilitation, Kita-Fukushima Medical Center, Date City, Fukushima, Japan.
  • Mogi Y; Department of Rehabilitation, Kita-Fukushima Medical Center, Date City, Fukushima, Japan.
  • Kasahara R; Department of Rehabilitation, Kita-Fukushima Medical Center, Date City, Fukushima, Japan.
  • Yamamoto Y; Department of Rehabilitation, Kita-Fukushima Medical Center, Date City, Fukushima, Japan.
  • Kai T; Department of Hematology, Kita-Fukushima Medical Center, Date City, Fukushima, Japan.
Medicine (Baltimore) ; 103(20): e38207, 2024 May 17.
Article en En | MEDLINE | ID: mdl-38758870
ABSTRACT
This study aimed to investigate changes in hand sensation (finger tactile threshold and two-point discrimination) and function in patients with malignant lymphoma, particularly during the early stages of chemotherapy with vincristine. Eighteen patients with malignant lymphoma were enrolled in this study. Data on the Common Terminology Criteria for Adverse Events Version 4.0, the visual analog scale for hand numbness, the Semmes Weinstein monofilament test, static and moving two-point discrimination (2PD), grip strength, pinch strength, and the Purdue Pegboard test were collected at 3 time points before the start of chemotherapy (T0), after the first cycle of chemotherapy (T1), and after the second cycle of chemotherapy (T2). No significant changes were observed in Semmes Weinstein monofilament test at T0, T1, or T2 in either hand. However, the static 2PD was significantly worse for the right ring, little, and left middle fingers, whereas the moving 2PD was significantly worse for the right ring, left index, middle, and ring fingers. Furthermore, the visual analog scale scores for hand numbness and left-hand grip strength worsened significantly. Right-hand grip strength, pinch strength of both hands, and Purdue Pegboard test showed no significant deterioration. Chemotherapy with vincristine may affect hand sensation and function in patients with malignant lymphoma by exacerbating finger 2PD and hand numbness. Additionally, during the early stages of vincristine chemotherapy, it is important to monitor for a decrease in grip strength specifically in the left hand.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vincristina / Fuerza de la Mano / Mano / Linfoma Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Medicine (Baltimore) Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vincristina / Fuerza de la Mano / Mano / Linfoma Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Medicine (Baltimore) Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos