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Evaluation of adverse reactions induced by anti-tuberculosis drugs among hospitalized patients in Wuhan, China: A retrospective study.
Shi, Cai; Yang, Boning; Yang, Jingxiang; Song, Wei; Chen, Ying; Zhang, Shuxiao; Zhan, Hanyan; Xiong, Yuanguo; Rong, Peipei; Luo, Yi; Yang, Jian.
Afiliación
  • Shi C; Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, China.
  • Yang B; Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, China.
  • Yang J; Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
  • Song W; Department of Pharmacy, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
  • Chen Y; Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, China.
  • Zhang S; Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, China.
  • Zhan H; Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, China.
  • Xiong Y; Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, China.
  • Rong P; Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, China.
  • Luo Y; Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, China.
  • Yang J; Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, China.
Medicine (Baltimore) ; 103(20): e38273, 2024 May 17.
Article en En | MEDLINE | ID: mdl-38758847
ABSTRACT
The study aims to estimate the incidence and risk factors of adverse drug reactions (ADRs) induced by anti-tuberculosis (TB) drugs. A single center retrospective analysis of patients taking anti-TB therapy from January 2016 to December 2018 in the hospital was conducted. Univariate and multivariate logistic regression analysis were used to identify these risk factors of ADRs induced by anti-TB drugs. Among 1430 patients receiving anti-TB therapy, 440 (30.77%) patients showed at least 1 ADR induced by anti-TB drugs. Hyperuricemia was the most common ADR, followed by hepatic function test abnormality, liver damage and gastrointestinal reactions. Significant differences (P < .05) were also seen in diabetes, age, treatment duration, type of TB (extrapulmonary) and some therapeutic regimens between ADR group and non-ADR group, respectively. Multivariate logistic regression analysis showed that treatment duration (OR = 1.029, 95%CI[1.018-1.040], P = .000), type of TB (extrapulmonary, OR = 1.487, 95%CI[1.134-1.952], P = .004) and some therapeutic regimens (HREZ, OR = 1.425, 95%CI[0.922-2.903], P = .001; HRZS, OR = 2.063, 95% CI[1.234-3.449], P = .006; HRZ, OR = 3.623, 95%CI[2.289-5.736], P = .000) were risk factors for ADRs induced by anti-TB drugs. Anti-TB drugs usually induced the occurrence of severe and frequent adverse effects, such as hyperuricemia. Treatment duration, HREZ, HRZS and HRZ regimens, and type of TB (extrapulmonary) should be considered as high-risk factors. Thus, it should be recommended to consider optimum management during anti-TB therapy, particularly hyperuricemia monitoring and hepatic function test.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antituberculosos Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Medicine (Baltimore) Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antituberculosos Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Medicine (Baltimore) Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos