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Design and application of Cd2+ polypeptide fluorescent probes based on Aggregation Induced Emission (AIE).
Zhou, Jiang; Wang, Xuejiao; Wang, Dajiang; Yuan, Liangchao; Hao, Junlei; Hou, Jingcheng; Wu, Jiang; Lin, Pengcheng.
Afiliación
  • Zhou J; Key Laboratory for Tibet Plateau Phytochemistry of Qinghai Province, College of Pharmacy, Qinghai Nationalities University, Xining, 810007, China.
  • Wang X; Key Laboratory for Tibet Plateau Phytochemistry of Qinghai Province, College of Pharmacy, Qinghai Nationalities University, Xining, 810007, China.
  • Wang D; Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, 610041, China.
  • Yuan L; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Institute of Artificial Intelligence Biomedicine, Engineering Research Center of Protein and Peptide Medicine, Nanjing University, Nanjing, 210023, P. R. China.
  • Hao J; Key Laboratory for Tibet Plateau Phytochemistry of Qinghai Province, College of Pharmacy, Qinghai Nationalities University, Xining, 810007, China.
  • Hou J; Key Laboratory for Tibet Plateau Phytochemistry of Qinghai Province, College of Pharmacy, Qinghai Nationalities University, Xining, 810007, China.
  • Wu J; Key Laboratory for Tibet Plateau Phytochemistry of Qinghai Province, College of Pharmacy, Qinghai Nationalities University, Xining, 810007, China. wujiang@lzu.edu.cn.
  • Lin P; Key Laboratory for Tibet Plateau Phytochemistry of Qinghai Province, College of Pharmacy, Qinghai Nationalities University, Xining, 810007, China. qhlpc@126.com.
J Mol Histol ; 55(4): 581-588, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38758519
ABSTRACT
Cadmium is a toxic heavy metal, which is both an environmental pollutant, and a threat to human health. A fluorescent probe was developed to detect Cd2+ selectively, sensitively, and quickly. This study reports the successful development of a polypeptide fluorescent probe TPE-HC (TPE-His-Pro-Gly-Cys) which selectively detects Cd2+ by Aggregation-Induced Emission effect. After fluorescence excitation, Cd2+ can be effectively detected based on the change of fluorescence intensity. The detection limit of Cd2+ in buffer solution was determined to be 151 nM (R2 = 0.9933). This probe exhibits high sensitivity, high cell permeabilit y, and low biological toxicity, and can perform live cell imaging under biological conditions. This study indicates that TPE-HC can detect Cd2+ in biological environments.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos / Cadmio / Colorantes Fluorescentes Límite: Humans Idioma: En Revista: J Mol Histol Asunto de la revista: HISTOCITOQUIMICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos / Cadmio / Colorantes Fluorescentes Límite: Humans Idioma: En Revista: J Mol Histol Asunto de la revista: HISTOCITOQUIMICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos