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The effects of intermittent theta burst stimulation over dorsal premotor cortex on primary motor cortex plasticity in young and older adults.
Liao, Wei-Yeh; Opie, George M; Ziemann, Ulf; Semmler, John G.
Afiliación
  • Liao WY; Discipline of Physiology, School of Biomedicine, The University of Adelaide, Adelaide, Australia.
  • Opie GM; Discipline of Physiology, School of Biomedicine, The University of Adelaide, Adelaide, Australia.
  • Ziemann U; Department of Neurology & Stroke, Eberhard Karls University of Tübingen, Tübingen, Germany.
  • Semmler JG; Hertie-Institute for Clinical Brain Research, Eberhard Karls University of Tübingen, Tübingen, Germany.
Eur J Neurosci ; 60(2): 4019-4033, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38757748
ABSTRACT
Previous transcranial magnetic stimulation (TMS) research suggests that the dorsal premotor cortex (PMd) influences neuroplasticity within the primary motor cortex (M1) through indirect (I) wave interneuronal circuits. However, it is unclear how the influence of PMd on the plasticity of M1 I-waves changes with advancing age. This study therefore investigated the neuroplastic effects of intermittent theta burst stimulation (iTBS) to M1 early and late I-wave circuits when preceded by iTBS (PMd iTBS-M1 iTBS) or sham stimulation (PMd sham-M1 iTBS) to PMd in 15 young and 16 older adults. M1 excitability was assessed with motor evoked potentials (MEP) recorded from the right first dorsal interosseous using posterior-anterior (PA) and anterior-posterior (AP) current TMS at standard stimulation intensities (PA1mV, AP1mV) and reduced stimulation intensities (PA0.5mV, early I-waves; AP0.5mV, late I-waves). PMd iTBS-M1 iTBS lowered the expected facilitation of PA0.5mV (to M1 iTBS) in young and older adults (P = 0.009), whereas the intervention had no effect on AP0.5mV facilitation in either group (P = 0.305). The modulation of PA0.5mV following PMd iTBS-M1 iTBS may reflect a specific influence of PMd on different I-wave circuits that are involved in M1 plasticity within young and older adults.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ritmo Teta / Potenciales Evocados Motores / Estimulación Magnética Transcraneal / Corteza Motora / Plasticidad Neuronal Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Neurosci Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Francia
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ritmo Teta / Potenciales Evocados Motores / Estimulación Magnética Transcraneal / Corteza Motora / Plasticidad Neuronal Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Neurosci Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Francia