Your browser doesn't support javascript.
loading
Active Targeting Hyaluronan Conjugated Nanoprobe for Magnetic Particle Imaging and Near-Infrared Fluorescence Imaging of Breast Cancer and Lung Metastasis.
Yang, Chia-Wei; Liu, Kunli; Yao, Cheng-You; Li, Bo; Juhong, Aniwat; Ullah, A K M Atique; Bumpers, Harvey; Qiu, Zhen; Huang, Xuefei.
Afiliación
  • Yang CW; Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, United States.
  • Liu K; Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, Michigan 48824, United States.
  • Yao CY; Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, United States.
  • Li B; Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, Michigan 48824, United States.
  • Juhong A; Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, Michigan 48824, United States.
  • Ullah AKMA; Department of Electrical and Computer Engineering, Michigan State University, East Lansing, Michigan 48824, United States.
  • Bumpers H; Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, Michigan 48824, United States.
  • Qiu Z; Department of Electrical and Computer Engineering, Michigan State University, East Lansing, Michigan 48824, United States.
  • Huang X; Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, Michigan 48824, United States.
ACS Appl Mater Interfaces ; 16(21): 27055-27064, 2024 May 29.
Article en En | MEDLINE | ID: mdl-38757711
ABSTRACT
A major contributing cause to breast cancer related death is metastasis. Moreover, breast cancer metastasis often shows little symptoms until a large area of the organs is occupied by metastatic cancer cells. Breast cancer multimodal imaging is attractive since it integrates advantages from several modalities, enabling more accurate cancer detection. Glycoprotein CD44 is overexpressed on most breast cancer cells and is the primary cell surface receptor for hyaluronan (HA). To facilitate breast cancer diagnosis, we report an indocyanine green (ICG) and HA conjugated iron oxide nanoparticle (NP-ICG-HA), which enabled active targeting to breast cancer by HA-CD44 interaction and detected metastasis with magnetic particle imaging (MPI) and near-infrared fluorescence imaging (NIR-FI). When evaluated in a transgenic breast cancer mouse model, NP-ICG-HA enabled the detection of multiple breast tumors in MPI and NIR-FI, providing more comprehensive images and a diagnosis of breast cancer. Furthermore, NP-ICG-HAs were evaluated in a lung metastasis model. Upon NP-ICG-HA administration, MPI showed clear signals in the lungs, indicating the tumor sites. This is the first time that HA-based NPs have enabled MPI of cancer. NP-ICG-HAs are an attractive platform for noninvasive detection of primary breast cancer and lung metastasis.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Imagen Óptica / Ácido Hialurónico / Verde de Indocianina / Neoplasias Pulmonares Límite: Animals / Female / Humans Idioma: En Revista: ACS Appl Mater Interfaces Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Imagen Óptica / Ácido Hialurónico / Verde de Indocianina / Neoplasias Pulmonares Límite: Animals / Female / Humans Idioma: En Revista: ACS Appl Mater Interfaces Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos