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Associations of CBC-Derived inflammatory indicators with sarcopenia and mortality in adults: evidence from Nhanes 1999 ∼ 2006.
Guo, Botang; Liu, Xinqing; Si, Qi; Zhang, Dongdong; Li, Minyao; Li, Xi; Zhao, Yang; Hu, Fulan; Zhang, Ming; Liu, Yu; Hu, Dongsheng.
Afiliación
  • Guo B; Department of General Practice, The Affiliated Luohu Hospital of Shenzhen University Medical School, YouYi Road 47, Shenzhen, 518000, Guangdong, People's Republic of China.
  • Liu X; College of Medical Administration, Harbin Medical University, Heilongjiang Province, Harbin, 150078, China.
  • Si Q; College of Medical Administration, Harbin Medical University, Heilongjiang Province, Harbin, 150078, China.
  • Zhang D; Department of General Practice, The Affiliated Luohu Hospital of Shenzhen University Medical School, YouYi Road 47, Shenzhen, 518000, Guangdong, People's Republic of China.
  • Li M; Department of General Practice, The Affiliated Luohu Hospital of Shenzhen University Medical School, YouYi Road 47, Shenzhen, 518000, Guangdong, People's Republic of China.
  • Li X; Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Henan Province, Zhengzhou, 450001, China.
  • Zhao Y; Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Henan Province, Zhengzhou, 450001, China.
  • Hu F; Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen University Medical School, Shenzhen, 518073, Guangdong Province, China.
  • Zhang M; Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen University Medical School, Shenzhen, 518073, Guangdong Province, China.
  • Liu Y; Department of General Practice, The Affiliated Luohu Hospital of Shenzhen University Medical School, YouYi Road 47, Shenzhen, 518000, Guangdong, People's Republic of China. yuliu890130@163.com.
  • Hu D; Department of General Practice, The Affiliated Luohu Hospital of Shenzhen University Medical School, YouYi Road 47, Shenzhen, 518000, Guangdong, People's Republic of China. dongshenghu563@126.com.
BMC Geriatr ; 24(1): 432, 2024 May 16.
Article en En | MEDLINE | ID: mdl-38755603
ABSTRACT

BACKGROUND:

It has been proposed that inflammation plays a role in the development of sarcopenia. This study aimed to investigate the links of complete blood cell count (CBC) parameters and CBC-derived inflammatory indicators with sarcopenia and mortality.

METHODS:

Data pertaining to sarcopenia were extracted from the 1999-2006 National Health and Nutrition Examination Survey (NHANES), and mortality events were ascertained through the National Death Index up to December 31, 2019. The CBC-derived inflammatory indicators assessed in this study included the neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (dNLR), monocyte-to-lymphocyte ratio (MLR), neutrophil-monocyte to lymphocyte ratio (NMLR), systemic inflammatory response index (SIRI), and systemic immune-inflammation index (SII). The prognostic significance of these CBC-derived inflammatory indicators was evaluated using the random survival forests (RSF) analysis.

RESULTS:

The study encompassed a cohort of 12,689 individuals, among whom 1,725 were diagnosed with sarcopenia. Among individuals with sarcopenia, 782 experienced all-cause mortality, and 195 succumbed to cardiovascular causes. Following adjustment for confounding variables, it was observed that elevated levels of NLR, dNLR, NMLR, SIRI, and SII were associated with an increased prevalence of sarcopenia. Among participants with sarcopenia, those in the highest quartile of NLR (HR = 1.336 [1.095-1.631]), dNLR (HR = 1.274 [1.046-1.550]), MLR (HR = 1.619 [1.290-2.032]), NMLR (HR = 1.390 [1.132-1.707]), and SIRI (HR = 1.501 [1.210-1.862]) exhibited an elevated risk of all-cause mortality compared to those in the lowest quartile of these inflammation-derived indicators. These associations were similarly observed in cardiovascular mortality (HR = 1.874 [1.169-3.003] for MLR, HR = 1.838 [1.175-2.878] for SIRI). The RSF analysis indicated that MLR exhibited the highest predictive power for both all-cause and cardiovascular mortality among individuals with sarcopenia.

CONCLUSIONS:

Our findings underscore the association between CBC-derived inflammatory indicators and mortality in adults with sarcopenia. Of note, MLR emerged as the most robust predictor of all-cause and cardiovascular mortality in this population.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encuestas Nutricionales / Sarcopenia / Inflamación Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: BMC Geriatr Asunto de la revista: GERIATRIA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encuestas Nutricionales / Sarcopenia / Inflamación Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: BMC Geriatr Asunto de la revista: GERIATRIA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido