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Subtype prediction of intrahepatic cholangiocarcinoma using dynamic contrast-enhanced ultrasound.
Zhu, Ming-Rui; Zhao, Chong-Ke; Sun, Yi-Kang; Li, Xiao-Long; Yin, Hao-Hao; Lu, Dan; Ye, Xin; Hu, Xin-Yuan; Wang, Xi; Xia, Han-Sheng; Han, Hong; Zhou, Bo-Yang; Xu, Hui-Xiong; Wang, Li-Fan.
Afiliación
  • Zhu MR; Department of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, 200032, Shanghai, China.
  • Zhao CK; Shanghai Institute of Medical Imaging, 200032, Shanghai, China.
  • Sun YK; Department of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, 200032, Shanghai, China.
  • Li XL; Shanghai Institute of Medical Imaging, 200032, Shanghai, China.
  • Yin HH; Department of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, 200032, Shanghai, China.
  • Lu D; Shanghai Institute of Medical Imaging, 200032, Shanghai, China.
  • Ye X; Department of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, 200032, Shanghai, China.
  • Hu XY; Shanghai Institute of Medical Imaging, 200032, Shanghai, China.
  • Wang X; Department of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, 200032, Shanghai, China.
  • Xia HS; Shanghai Institute of Medical Imaging, 200032, Shanghai, China.
  • Han H; Department of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, 200032, Shanghai, China.
  • Zhou BY; Shanghai Institute of Medical Imaging, 200032, Shanghai, China.
  • Xu HX; Department of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, 200032, Shanghai, China.
  • Wang LF; Shanghai Institute of Medical Imaging, 200032, Shanghai, China.
Insights Imaging ; 15(1): 119, 2024 May 16.
Article en En | MEDLINE | ID: mdl-38755299
ABSTRACT

OBJECTIVE:

The study aimed to investigate the predictive value of dynamic contrast-enhanced ultrasound (DCE-US) in differentiating small-duct (SD) and large-duct (LD) types of intrahepatic cholangiocarcinoma (ICC).

METHODS:

This study retrospectively enrolled 110 patients with pathologically confirmed ICC lesions who were subject to preoperative contrast-enhanced ultrasound (CEUS) examinations between January 2022 and February 2023. Patients were further classified according to the subtype SD-type and LD-type, and an optimal predictive model was established and validated using the above pilot cohort. The test cohort, consisting of 48 patients prospectively enrolled from March 2023 to September 2023, was evaluated.

RESULTS:

In the pilot cohort, compared with SD-type ICCs, more LD-type ICCs showed elevated carcinoembryonic antigen (p < 0.001), carbohydrate antigen 19-9 (p = 0.004), ill-defined margin (p = 0.018), intrahepatic bile duct dilation (p < 0.001). Among DCE-US quantitative parameters, the wash-out area under the curve (WoAUC), wash-in and wash-out area under the curve (WiWoAUC), and fall time (FT) at the margin of lesions were higher in the SD-type group (all p < 0.05). Meanwhile, the mean transit time (mTT) and wash-out rate (WoR) at the margin of the lesion were higher in the LD-type group (p = 0.041 and 0.007, respectively). Logistic regression analysis showed that intrahepatic bile duct dilation, mTT, and WoR were significant predictive factors for predicting ICC subtypes, and the AUC of the predictive model achieved 0.833 in the test cohort.

CONCLUSIONS:

Preoperative DCE-US has the potential to become a novel complementary method for predicting the pathological subtype of ICC. CRITICAL RELEVANCE STATEMENT DCE-US has the potential to assess the subtypes of ICC lesions quantitatively and preoperatively, which allows for more accurate and objective differential diagnoses, and more appropriate treatments and follow-up or additional examination strategies for the two subtypes. KEY POINTS Preoperative determination of intrahepatic cholangiocarcinoma (ICC) subtype aids in surgical decision-making. Quantitative parameters from dynamic contrast-enhanced US (DCE-US) allow for the prediction of the ICC subtype. DCE-US-based imaging has the potential to become a novel complementary method for predicting ICC subtypes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Insights Imaging Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Insights Imaging Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania