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Nano­selenium alleviates cadmium-induced blood-brain barrier destruction by restoring the Wnt7A/ß-catenin pathway.
Li, Chen-Xi; Talukder, Milton; Wang, Zhao-Yi; Zhu, Shi-Yong; Xu, Ya-Ru; Li, Xue-Nan; Li, Jin-Long.
Afiliación
  • Li CX; College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China.
  • Talukder M; College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China; Department of Physiology and Pharmacology, Faculty of Animal Science and Veterinary Medicine, Patuakhali Science and Technology University, Barishal 8210, Bangladesh.
  • Wang ZY; College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China.
  • Zhu SY; College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China; College of Veterinary Medicine, Qingdao Agricultural University, Qingdao 266109, PR China.
  • Xu YR; College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China.
  • Li XN; College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China; Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, Northeast Agricultural University, Harbin 150030, PR China; Heilongjiang Key Laborator
  • Li JL; College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China; Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, Northeast Agricultural University, Harbin 150030, PR China; Heilongjiang Key Laborator
Sci Total Environ ; 935: 173249, 2024 Jul 20.
Article en En | MEDLINE | ID: mdl-38754502
ABSTRACT
Selenium (Se), a highly beneficial animal feed additive, exhibits remarkable antioxidant and anti-inflammatory properties. Nano­selenium (Nano-Se) is an advanced formulation of Se featuring a specialized drug delivery vehicle, with good bioavailability, higher efficacy, and lower toxicity compared to the traditional form of Se. With the advancement of industry, cadmium (Cd) contamination occurs in different countries and regions and thereby contaminating different food crops, and the degree of pollution is degree increasing year by year. The present investigation entailed the oral administration of CdCl2 and/or Nano-Se to male chickens of the Hy-Line Variety White breed, which are one day old, subsequent to a 7-day adaptive feeding period, for a duration of 90 days. The study aimed to elucidate the potential protective impact of Nano-Se on Cd exposure. The study found that Nano-Se demonstrates potential in mitigating the blood-brain barrier (BBB) dysfunction characterized by impairment of adherens junctions (AJS) and tight junctions (TJS) by inhibiting reactive oxygen species (ROS) overproduction. In addition, the data uncovered that Nano-Se demonstrates a proficient ability in alleviating BBB impairment and inflammatory reactions caused by Cd through the modulation of the Wnt7A/ß-catenin pathway, highlights its potential to maintain brain homeostasis. Hence, this research anticipates that the utilization of Nano-Se effectively mitigate the detrimental impacts associated with Cd exposure on the BBB.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Selenio / Cadmio / Barrera Hematoencefálica / Pollos Límite: Animals Idioma: En Revista: Sci Total Environ Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Selenio / Cadmio / Barrera Hematoencefálica / Pollos Límite: Animals Idioma: En Revista: Sci Total Environ Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos