Your browser doesn't support javascript.
loading
Loading enhances glucose uptake in muscles, bones, and bone marrow of lower extremities in humans.
Bellman, Jakob; Sjöros, Tanja; Hägg, Daniel; Atencio Herre, Erika; Hieta, Janina; Eskola, Olli; Laitinen, Kirsi; Nuutila, Pirjo; Jansson, John-Olov; Jansson, Per-Anders; Kalliokoski, Kari; Roivainen, Anne; Ohlsson, Claes.
Afiliación
  • Bellman J; Department of Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
  • Sjöros T; Turku PET Centre, University of Turku, Turku, Finland.
  • Hägg D; Turku PET Centre, Turku University Hospital, Turku, Finland.
  • Atencio Herre E; Department of Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
  • Hieta J; Turku PET Centre, University of Turku, Turku, Finland.
  • Eskola O; Turku PET Centre, Turku University Hospital, Turku, Finland.
  • Laitinen K; Nutrition and Food Research Center and Institute of Biomedicine, Integrative Physiology and Pharmacology Unit, Faculty of Medicine, University of Turku, Turku, Finland.
  • Nuutila P; Turku PET Centre, University of Turku, Turku, Finland.
  • Jansson JO; Nutrition and Food Research Center and Institute of Biomedicine, Integrative Physiology and Pharmacology Unit, Faculty of Medicine, University of Turku, Turku, Finland.
  • Jansson PA; Turku PET Centre, University of Turku, Turku, Finland.
  • Kalliokoski K; Turku PET Centre, Turku University Hospital, Turku, Finland.
  • Roivainen A; Department of Endocrinology, Turku University Hospital, Turku, Finland.
  • Ohlsson C; Department of Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
J Clin Endocrinol Metab ; 2024 May 16.
Article en En | MEDLINE | ID: mdl-38753869
ABSTRACT
CONTEXT Increased standing time has been associated with improved health, but the underlying mechanism is unclear.

OBJECTIVES:

We herein investigate if increased weight loading increases energy demand and thereby glucose uptake (GU) locally in bone and/or muscle in the lower extremities.

METHODS:

In this single-center clinical trial with randomized crossover design (ClinicalTrials.gov ID, NCT05443620), we enrolled 10 men with body mass index (BMI) between 30 and 35 kg/m2. Participants were treated with both high load (standing with weight vest weighing 11% of body weight) and no load (sitting) on the lower extremities. GU was measured using whole-body quantitative positron emission tomography/computed tomography (PET/CT) imaging. The primary endpoint was the change in GU ratio between loaded bones (i.e. femur and tibia) and non-loaded bones (i.e. humerus).

RESULTS:

High load increased the GU ratio between lower and upper extremities in cortical diaphyseal bone (e.g. femur/humerus ratio increased by 19%, p = 0.029), muscles (e.g. m. quadriceps femoris/m. triceps brachii ratio increased by 28%, p = 0.014) and in certain bone marrow regions (femur/humerus diaphyseal bone marrow region ratio increased by 17%, p = 0.041). Unexpectedly, we observed the highest GU in the bone marrow region of vertebral bodies, but its GU was not affected by high load.

CONCLUSIONS:

Increased weight-bearing loading enhances GU in muscles, cortical bone, and bone marrow of the exposed lower extremities. This could be interpreted as increased local energy demand in bone and muscle caused by increased loading. The physiological importance of the increased local GU by static loading remains to be determined.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Endocrinol Metab Año: 2024 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Endocrinol Metab Año: 2024 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos