Suberitolactams A-D and Suberitopyridines A-B: New Î³-lactam and Pyridine Alkaloids Isolated from the South China Sea Sponge Pseudospongosorites suberitoides.

Wang, Zhe; Li, Guo-Qiang; Zhang, Han-Ting

Wang, Zhe; Li, Guo-Qiang; Zhang, Han-Ting.

Afiliación

Wang Z; Department of Pharmacology, School of Pharmacy, Qingdao University, Qingdao, 266071, People's Republic of China.
Li GQ; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, People's Republic of China.
Zhang HT; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, People's Republic of China.

Chem Biodivers ; 21(8): e202400939, 2024 Aug.

Article en En | MEDLINE | ID: mdl-38752887

ABSTRACT

ABSTRACT

Four new Î³-lactam alkaloids, suberitolactams A-D (1-4), two new pyridine alkaloids, suberitopyridines A-B (7-8), and two known compounds (5-6) were isolated from the South China Sea sponge Pseudospongosorites suberitoides. The structures were elucidated by detailed 1D and 2D NMR experiments along with HRESIMS analysis and single crystal X-ray diffraction. Compoundsâ1 and 8 showed moderate to weak antiviral activity against H1âN1 virus with IC50 values of 27.6 and 13.3âµM, respectively.

Asunto(s)

Alcaloides; Antivirales; Lactamas; Poríferos; Piridinas; Animales; Alcaloides/aislamiento & purificación; Alcaloides/química; Alcaloides/farmacología; Poríferos/química; Lactamas/química; Lactamas/aislamiento & purificación; Lactamas/farmacología; Piridinas/química; Piridinas/aislamiento & purificación; Piridinas/farmacología; Antivirales/farmacología; Antivirales/química; Antivirales/aislamiento & purificación; China; Subtipo H1N1 del Virus de la Influenza A/efectos de los fármacos; Cristalografía por Rayos X; Estructura Molecular; Conformación Molecular; Modelos Moleculares

Palabras clave

Pseudospongosorites suberitoides; X-ray diffraction; alkaloids; antiviral activity

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Poríferos / Piridinas / Alcaloides / Lactamas Límite: Animals País/Región como asunto: Asia Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2024 Tipo del documento: Article Pais de publicación: Suiza

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google