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Two new withanolides from Physalis minima L.
Zhang, Li-Jie; Peng, Mei-Lin; Xu, Shi-Ying; Wang, Fu-Rui; Yu, Lin-Lin; Zhu, Qin-Feng; Liao, Shang-Gao; Xu, Guo-Bo.
Afiliación
  • Zhang LJ; School of Pharmacy, Guizhou Medical University, Guizhou, China.
  • Peng ML; University Engineering Research Center for the Prevention and Treatment of Chronic Diseases by Authentic Medicinal Materials in Guizhou Province, Guizhou, China.
  • Xu SY; Engineering Research Center for the Development and Application of Ethnic Medicine and TCM, Ministry of Education, Guiyang, Guizhou, China.
  • Wang FR; School of Pharmacy, Guizhou Medical University, Guizhou, China.
  • Yu LL; School of Pharmacy, Guizhou Medical University, Guizhou, China.
  • Zhu QF; School of Pharmacy, Guizhou Medical University, Guizhou, China.
  • Liao SG; School of Pharmacy, Guizhou Medical University, Guizhou, China.
  • Xu GB; University Engineering Research Center for the Prevention and Treatment of Chronic Diseases by Authentic Medicinal Materials in Guizhou Province, Guizhou, China.
Nat Prod Res ; : 1-7, 2024 May 16.
Article en En | MEDLINE | ID: mdl-38752874
ABSTRACT
Two new withanolides named physaminilides L (1) and M (2), together with four known ones (3-6) were isolated from the Physalis minima L. The structures were established by analysis of the HR ESIMS, IR and NMR spectroscopic data. The absolute configurations were determined through NOESY and ECD spectra. For compounds 1-5 assayed at 20 µM and compound 6 at 10 µM, inhibition rates of hepatic fibrosis were 22.19%, 15.29%, 37.07%, 9.27%, 12.45%, and 37.03%, respectively.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nat Prod Res Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Nat Prod Res Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido