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ACVIM consensus statement on the diagnosis of immune thrombocytopenia in dogs and cats.
LeVine, Dana N; Kidd, Linda; Garden, Oliver A; Brooks, Marjory B; Goggs, Robert; Kohn, Barbara; Mackin, Andrew J; Eldermire, Erin R B; Chang, Yu-Mei; Allen, Julie; Christopherson, Peter W; Glanemann, Barbara; Maruyama, Haruhiko; Naskou, Maria C; Nielsen, Lise N; Shropshire, Sarah; Viall, Austin K; Birkenheuer, Adam J; Forman, Marnin A; Hanzlicek, Andrew S; Langner, Kathrin F; Lashnits, Erin; Lunn, Katharine F; Makielski, Kelly M; Roura, Xavier; Spada, Eva.
Afiliación
  • LeVine DN; Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, Alabama, USA.
  • Kidd L; Western University of Health Sciences College of Veterinary Medicine, Pomona, California, USA.
  • Garden OA; Zoetis Animal Health Diagnostics, Parsippany, New Jersey, USA.
  • Brooks MB; School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, USA.
  • Goggs R; Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
  • Kohn B; Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
  • Mackin AJ; Clinic for Small Animals, Faculty of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany.
  • Eldermire ERB; College of Veterinary Medicine, Mississippi State University, Starkville, Mississippi, USA.
  • Chang YM; Flower-Sprecher Veterinary Library, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
  • Allen J; Department of Comparative Biomedical Sciences, Royal Veterinary College, London, UK.
  • Christopherson PW; Veterinary Information Network, Davis, California, USA.
  • Glanemann B; Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, Alabama, USA.
  • Maruyama H; Department of Clinical Science and Services, Royal Veterinary College, University of London, London, UK.
  • Naskou MC; Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Chiyoda City, Japan.
  • Nielsen LN; Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, Alabama, USA.
  • Shropshire S; Department of Veterinary Clinical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Viall AK; College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.
  • Birkenheuer AJ; Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, California, USA.
  • Forman MA; College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA.
  • Hanzlicek AS; Cornell University Veterinary Specialists, Stamford, Connecticut, USA.
  • Langner KF; MiraVista Veterinary Diagnostics, Indianapolis, Indiana, USA.
  • Lashnits E; Western Australian Veterinary Emergency and Specialty, Perth, Australia.
  • Lunn KF; School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, USA.
  • Makielski KM; Axiom Veterinary Laboratories, Newton Abbot, Devon, UK.
  • Roura X; College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota, USA.
  • Spada E; Hospital Clinic Veterinari, Universitat Autonoma de Barcelona, Bellaterra, Spain.
J Vet Intern Med ; 38(4): 1958-1981, 2024.
Article en En | MEDLINE | ID: mdl-38752421
ABSTRACT
Immune thrombocytopenia (ITP) is the most common acquired primary hemostatic disorder in dogs. Immune thrombocytopenia less commonly affects cats but is an important cause of mortality and treatment-associated morbidity in both species. Immune thrombocytopenia remains a diagnosis of exclusion for which diagnostic guidelines are lacking. Primary, or non-associative, ITP refers to autoimmune platelet destruction. Secondary, or associative, ITP arises in response to an underlying disease trigger. However, evidence for which comorbidities serve as ITP triggers has not been systematically evaluated. To identify key diagnostic steps for ITP and important comorbidities associated with secondary ITP, we developed 12 Population Evaluation/Exposure Comparison Outcome (PECO) format questions. These questions were addressed by evidence evaluators utilizing a literature pool of 287 articles identified by the panelists using a structured search strategy. Evidence evaluators, using panel-designed templates and data extraction tools, summarized evidence and created guideline recommendations that then were integrated by diagnosis and comorbidity domain chairs. The revised PECO responses underwent a Delphi survey process to reach consensus on final guidelines. A combination of panel expertise and PECO responses were employed to develop algorithms for diagnosis of ITP in dogs and cats, which also underwent 4 iterations of Delphi review. Comorbidity evidence evaluators employed an integrated measure of evidence (IME) tool to determine evidence quality for each comorbidity; IME values combined with evidence summaries for each comorbidity were integrated to develop ITP screening recommendations, which also were subjected to Delphi review. Commentary was solicited from multiple relevant professional organizations before finalizing the consensus. The final consensus statement provides clinical guidelines for the diagnosis of, and underlying disease screening for, ITP in dogs and cats. The systematic consensus process identified numerous knowledge gaps that should guide future studies. This statement is a companion manuscript to the ACVIM Consensus Statement on the Treatment of Immune Thrombocytopenia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de los Gatos / Púrpura Trombocitopénica Idiopática / Enfermedades de los Perros Límite: Animals Idioma: En Revista: J Vet Intern Med Asunto de la revista: MEDICINA INTERNA / MEDICINA VETERINARIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de los Gatos / Púrpura Trombocitopénica Idiopática / Enfermedades de los Perros Límite: Animals Idioma: En Revista: J Vet Intern Med Asunto de la revista: MEDICINA INTERNA / MEDICINA VETERINARIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos