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Metabolic trajectories of diabetic ketoacidosis onset described by breath analysis.
Awchi, Mo; Singh, Kapil Dev; Brenner, Sara Bachmann; Burckhardt, Marie-Anne; Hess, Melanie; Zeng, Jiafa; Datta, Alexandre N; Frey, Urs; Zumsteg, Urs; Szinnai, Gabor; Sinues, Pablo.
Afiliación
  • Awchi M; University Children's Hospital Basel, Basel, Switzerland.
  • Singh KD; Department of Biomedical Engineering, University of Basel, Basel, Switzerland.
  • Brenner SB; University Children's Hospital Basel, Basel, Switzerland.
  • Burckhardt MA; Department of Biomedical Engineering, University of Basel, Basel, Switzerland.
  • Hess M; University Children's Hospital Basel, Basel, Switzerland.
  • Zeng J; Department of Clinical Research, University of Basel, Basel, Switzerland.
  • Datta AN; University Children's Hospital Basel, Basel, Switzerland.
  • Frey U; Department of Clinical Research, University of Basel, Basel, Switzerland.
  • Zumsteg U; University Children's Hospital Basel, Basel, Switzerland.
  • Szinnai G; Department of Clinical Research, University of Basel, Basel, Switzerland.
  • Sinues P; University Children's Hospital Basel, Basel, Switzerland.
Front Endocrinol (Lausanne) ; 15: 1360989, 2024.
Article en En | MEDLINE | ID: mdl-38752172
ABSTRACT

Purpose:

This feasibility study aimed to investigate the use of exhaled breath analysis to capture and quantify relative changes of metabolites during resolution of acute diabetic ketoacidosis under insulin and rehydration therapy.

Methods:

Breath analysis was conducted on 30 patients of which 5 with DKA. They inflated Nalophan bags, and their metabolic content was subsequently interrogated by secondary electrospray ionization high-resolution mass spectrometry (SESI-HRMS).

Results:

SESI-HRMS analysis showed that acetone, pyruvate, and acetoacetate, which are well known to be altered in DKA, were readily detectable in breath of participants with DKA. In addition, a total of 665 mass spectral features were found to significantly correlate with base excess and prompt metabolic trajectories toward an in-control state as they progress toward homeostasis.

Conclusion:

This study provides proof-of-principle for using exhaled breath analysis in a real ICU setting for DKA monitoring. This non-invasive new technology provides new insights and a more comprehensive overview of the effect of insulin and rehydration during DKA treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pruebas Respiratorias / Cetoacidosis Diabética / Insulina Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Front Endocrinol (Lausanne) Año: 2024 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pruebas Respiratorias / Cetoacidosis Diabética / Insulina Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Front Endocrinol (Lausanne) Año: 2024 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Suiza