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Association between dopamine receptor D2 Taq IA gene polymorphism (rs1800497) and personality traits.
Olasore, Holiness S A; Oyedeji, Tolulope A; Faleti, Joseph O; Ogundele, Omobola I; Olashore, Anthony A.
Afiliación
  • Olasore HSA; Faculty of Basic Medical Sciences, Department of Biochemistry, College of Medicine of the University of Lagos, Idi Araba, Lagos, Nigeria.
  • Oyedeji TA; Faculty of Basic Medical Sciences, Department of Biochemistry, College of Medicine of the University of Lagos, Idi Araba, Lagos, Nigeria.
  • Faleti JO; Faculty of Basic Medical Sciences, Department of Biochemistry, College of Medicine of the University of Lagos, Idi Araba, Lagos, Nigeria.
  • Ogundele OI; Faculty of Basic Medical Sciences, Department of Biochemistry, College of Medicine of the University of Lagos, Idi Araba, Lagos, Nigeria.
  • Olashore AA; Faculty of Medicine, Department of Psychiatry, University of Botswana, Gaborone, Botswana.
SAGE Open Med ; 12: 20503121241241922, 2024.
Article en En | MEDLINE | ID: mdl-38751571
ABSTRACT

Objective:

This study aimed to find a potential association between the DRD2 Taq1A gene polymorphism (rs1800497 C32806T) and personality traits.

Methods:

In all, 249 youths were recruited for this study. The Short-form Revised Eysenck Personality Questionnaire was administered to assess personality traits. The participants were genotyped for the DRD2 Taq1A polymorphism using the polymerase chain reaction-restriction fragment length polymorphism method. Statistical analysis was carried out to find a possible association between the genotypes and aspects of personality traits assessed.

Results:

The frequencies of the A1 and A2 alleles in our sampled population were 215 (43.2%) and 283 (56.8%), while the frequencies of A1A1, A1A2, and A2A2 were 67 (26.9%), 81 (32.5%), and 101 (40.6%), respectively. The study population was not in Hardy-Weinberg equilibrium (χ2 = 17.64, p < 0.001). The A2 allele was significantly associated with extraversion. Although this allele was also associated with neuroticism, psychoticism, and lie, the association was not significant.

Conclusion:

The A2 allele of the DRD2 Taq1A polymorphism was found to be more associated with extraversion, as measured by the Short-form Revised Eysenck Personality Questionnaire.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: SAGE Open Med Año: 2024 Tipo del documento: Article País de afiliación: Nigeria Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: SAGE Open Med Año: 2024 Tipo del documento: Article País de afiliación: Nigeria Pais de publicación: Reino Unido