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Association of serum protein electrophoresis with clinicopathological characteristics and its prognostic relevance in chronic lymphocytic leukaemia patients.
Hameed, Aisha; Sajid, Nadia; Javaid, Rabia Basri; Ali, Nadir.
Afiliación
  • Hameed A; Department of Pathology, Gujranwala Medical college, DHQ Teaching Hospital, Gujranwala.
  • Sajid N; Department of Clinical Hematology, Institute of Nuclear Medicine and Oncology Cancer Hospital, Lahore.
  • Javaid RB; Department of Human Genetics and Molecular Biology, University of Health Sciences, Lahore.
  • Ali N; Department of Hematology, Kulsum International Hospital, Islamabad, Pakistan.
J Pak Med Assoc ; 74(4): 711-718, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38751267
ABSTRACT

Objective:

To assess the association of serum protein electrophoresis abnormalities with clinicopathological characteristics, and its impact on overall survival in chronic lymphocytic leukaemia patients.

METHODS:

The prospective study was conducted at Haematology and Immunology departments of the University of Health Sciences, Lahore, Pakistan, from 2019 to 2022, and comprised newly diagnosed chronic lymphocytic leukaemia patients. Lactate dehydrogenase and beta-2 microglobulin levels were measured by spectrophotometric principle, whereas serum protein electrophoresis was determined through commercially available capillary electrophoresis systems. Patients were followed up for 2 years post-diagnosis. Data was analysed using SPSS 21.

RESULTS:

Of the 50 patients, 40(80%) were males and 10(20%) were females. The overall mean age was 60±11 years. Serum protein electrophoresis was available for 40(80%) patients, and, among them, 12(30%) patients had abnormal levels, while 29(72.5%) required treatment. Overall response rate was 25(86.2%), and median two-year overall survival was 16.5 months (95% confidence interval 10-20 months). Abnormal serum protein electrophoresis was significantly associated with Binet stage C, lower mean haemoglobin levels and higher median levels of lactate dehydrogenase and beta-2 microglobulin (p<0.05)). Regarding overall survival, the survival curves of chronic lymphocytic leukaemia patients with normal and abnormal serum protein electrophoresis status differed significantly (p=0.04).

Conclusion:

Abnormal serum protein electrophoresis could be considered a surrogate marker for advanced chronic lymphocytic leukaemia disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Electroforesis de las Proteínas Sanguíneas / Leucemia Linfocítica Crónica de Células B / Microglobulina beta-2 / L-Lactato Deshidrogenasa Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: J Pak Med Assoc Año: 2024 Tipo del documento: Article Pais de publicación: Pakistán
Texto completo
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Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Electroforesis de las Proteínas Sanguíneas / Leucemia Linfocítica Crónica de Células B / Microglobulina beta-2 / L-Lactato Deshidrogenasa Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: J Pak Med Assoc Año: 2024 Tipo del documento: Article Pais de publicación: Pakistán