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Retinal small vessel pathology is associated with disease burden in multiple sclerosis.
Wicklein, Rebecca; Kreitner, Linus; Wild, Anna; Aly, Lilian; Rueckert, Daniel; Hemmer, Bernhard; Korn, Thomas; Menten, Martin J; Knier, Benjamin.
Afiliación
  • Wicklein R; Department of Neurology, Klinikum rechts der Isar, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.
  • Kreitner L; Institute for AI and Informatics in Medicine, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.
  • Wild A; Department of Neurology, Klinikum rechts der Isar, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.
  • Aly L; Department of Neurology, Klinikum rechts der Isar, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.
  • Rueckert D; Institute for AI and Informatics in Medicine, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.
  • Hemmer B; BioMedIA, Imperial College London, London, UK.
  • Korn T; Department of Neurology, Klinikum rechts der Isar, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.
  • Menten MJ; Munich Cluster of Systems Neurology (SyNergy), Munich, Germany.
  • Knier B; Department of Neurology, Klinikum rechts der Isar, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.
Mult Scler ; 30(7): 812-819, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38751230
ABSTRACT

BACKGROUND:

Alterations of the superficial retinal vasculature are commonly observed in multiple sclerosis (MS) and can be visualized through optical coherence tomography angiography (OCTA).

OBJECTIVES:

This study aimed to examine changes in the retinal vasculature during MS and to integrate findings into current concepts of the underlying pathology.

METHODS:

In this cross-sectional study, including 259 relapsing-remitting MS patients and 78 healthy controls, we analyzed OCTAs using deep-learning-based segmentation algorithm tools.

RESULTS:

We identified a loss of small-sized vessels (diameter < 10 µm) in the superficial vascular complex in all MS eyes, irrespective of their optic neuritis (ON) history. This alteration was associated with MS disease burden and appears independent of retinal ganglion cell loss. In contrast, an observed reduction of medium-sized vessels (diameter 10-20 µm) was specific to eyes with a history of ON and was closely linked to ganglion cell atrophy.

CONCLUSION:

These findings suggest distinct atrophy patterns in retinal vessels in patients with MS. Further studies are necessary to investigate retinal vessel alterations and their underlying pathology in MS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vasos Retinianos / Neuritis Óptica / Esclerosis Múltiple Recurrente-Remitente / Tomografía de Coherencia Óptica Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Mult Scler Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vasos Retinianos / Neuritis Óptica / Esclerosis Múltiple Recurrente-Remitente / Tomografía de Coherencia Óptica Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Mult Scler Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido