Your browser doesn't support javascript.
loading
Clinical and molecular correlates of the Index of Severity for Eosinophilic Esophagitis.
Sato, Hiroki; Dellon, Evan S; Aceves, Seema S; Arva, Nicoleta C; Chehade, Mirna; Collins, Margaret H; Davis, Carla M; Falk, Gary W; Furuta, Glenn T; Gonsalves, Nirmala P; Gupta, Sandeep K; Hirano, Ikuo; Hiremath, Girish; Katzka, David A; Khoury, Paneez; Leung, John; Menard-Katcher, Paul; Pesek, Robbie; Peterson, Kathryn A; Pletneva, Maria A; Spergel, Jonathan M; Wechsler, Joshua B; Yang, Guang-Yu; Rothenberg, Marc E; Shoda, Tetsuo.
Afiliación
  • Sato H; Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
  • Dellon ES; University of North Carolina, Chapel Hill, NC.
  • Aceves SS; University of California San Diego School of Medicine, San Diego, Rady Children's Hospital, San Diego, Calif.
  • Arva NC; Nationwide Children's Hospital, Columbus, Ohio.
  • Chehade M; Icahn School of Medicine at Mount Sinai, New York, NY.
  • Collins MH; Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
  • Davis CM; Baylor College of Medicine, Texas Children's Hospital, Houston, Tex.
  • Falk GW; Penn Medicine, Philadelphia, Pa.
  • Furuta GT; Children's Hospital Colorado, Aurora, Colo.
  • Gonsalves NP; Northwestern University Feinberg School of Medicine, Chicago, Ill.
  • Gupta SK; University of Alabama at Birmingham, Birmingham, Ala.
  • Hirano I; Northwestern University Feinberg School of Medicine, Chicago, Ill.
  • Hiremath G; Vanderbilt University Medical Center, Nashville, Tenn.
  • Katzka DA; Columbia University Irving Medical Center, New York, NY.
  • Khoury P; National Institutes of Health, Bethesda, Md.
  • Leung J; Boston Specialists, Boston, Mass.
  • Menard-Katcher P; University of Colorado Anschutz Medical Campus, Aurora, Colo.
  • Pesek R; University of Arkansas for Medical Science, Little Rock, Ark.
  • Peterson KA; University of Utah Health, Salt Lake City, Utah.
  • Pletneva MA; University of Utah Health, Salt Lake City, Utah.
  • Spergel JM; Children's Hospital of Philadelphia, Philadelphia, Pa.
  • Wechsler JB; Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Ill.
  • Yang GY; Northwestern University Feinberg School of Medicine, Chicago, Ill.
  • Rothenberg ME; Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; University of Cincinnati College of Medicine, Cincinnati, Ohio.
  • Shoda T; Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; University of Cincinnati College of Medicine, Cincinnati, Ohio. Electronic address: Tetsuo.Shoda@cchmc.org.
J Allergy Clin Immunol ; 154(2): 375-386.e4, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38750825
ABSTRACT

BACKGROUND:

The Index of Severity for Eosinophilic Esophagitis (I-SEE) is a new expert-defined clinical tool that classifies disease severity of eosinophilic esophagitis (EoE).

OBJECTIVE:

We aimed to determine whether I-SEE is associated with patient characteristics, molecular features of EoE, or both.

METHODS:

We analyzed a prospective cohort of patients with EoE from the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR). Associations between I-SEE and clinical and molecular features (assessed by an EoE diagnostic panel [EDP]) were assessed.

RESULTS:

In 318 patients with chronic EoE (209 adults, 109 children), median total I-SEE score was 7.0, with a higher symptoms and complications score in children than adults (4.0 vs 1.0; P < .001) and higher inflammatory and fibrostenotic features scores in adults than children (3.0 vs 1.0 and 3.0 vs 0, respectively; both P < .001). Total I-SEE score had a bimodal distribution with the inactive to moderate categories and severe category. EDP score correlated with total I-SEE score (r = -0.352, P < .001) and both inflammatory and fibrostenotic features scores (r = -0.665, P < .001; r = -0.446, P < .001, respectively), but not with symptoms and complications scores (r = 0.047, P = .408). Molecular severity increased from inactive to mild and moderate, but not severe, categories. Longitudinal changes of modified I-SEE scores and inflammatory and fibrostenotic features scores reflected histologic and molecular activity.

CONCLUSIONS:

I-SEE score is associated with select clinical features across severity categories and with EoE molecular features for nonsevere categories, warranting further validation.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Índice de Severidad de la Enfermedad / Esofagitis Eosinofílica Límite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male / Middle aged Idioma: En Revista: J Allergy Clin Immunol Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Índice de Severidad de la Enfermedad / Esofagitis Eosinofílica Límite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male / Middle aged Idioma: En Revista: J Allergy Clin Immunol Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos