Your browser doesn't support javascript.
loading
Significance of absolute neutrophil count before allogeneic hematopoietic stem cell transplantation in adult patients with aplastic anemia.
Nakamura, Yukinori; Zaimoku, Yoshitaka; Yamaguchi, Hiroki; Yamazaki, Hirohito; Kanaya, Minoru; Uchida, Naoyuki; Doki, Noriko; Sakurai, Masatoshi; Hiramoto, Nobuhiro; Kako, Shinichi; Onizuka, Makoto; Onodera, Koichi; Maruyama, Yumiko; Ohigashi, Hiroyuki; Nishida, Tetsuya; Yoshihara, Satoshi; Matsuoka, Ken-Ichi; Eto, Tetsuya; Kanda, Yoshinobu; Fukuda, Takahiro; Atsuta, Yoshiko; Onishi, Yasushi.
Afiliación
  • Nakamura Y; Third Department of Internal Medicine, Yamaguchi University Hospital, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8505, Japan. nakay@yamaguchi-u.ac.jp.
  • Zaimoku Y; Department of Infection Control and Prevention, Kanazawa University Hospital, Ishikawa, Japan.
  • Yamaguchi H; Department of Hematology, Nippon Medical School, Tokyo, Japan.
  • Yamazaki H; Division of Transfusion Medicine, Kanazawa University Hospital, Ishikawa, Japan.
  • Kanaya M; Blood Disorders Center, Aiiku Hospital, Hokkaido, Japan.
  • Uchida N; Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital, Tokyo, Japan.
  • Doki N; Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan.
  • Sakurai M; Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
  • Hiramoto N; Department of Hematology, Kobe City Medical Center General Hospital, Hyogo, Japan.
  • Kako S; Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan.
  • Onizuka M; Department of Hematology/Oncology, Tokai University School of Medicine, Kanagawa, Japan.
  • Onodera K; Department of Hematology, Tohoku University Hospital, Miyagi, Japan.
  • Maruyama Y; Department of Hematology, University of Tsukuba Hospital, Ibaraki, Japan.
  • Ohigashi H; Department of Hematology, Hokkaido University Hospital, Hokkaido, Japan.
  • Nishida T; Department of Hematology, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, Aichi, Japan.
  • Yoshihara S; Department of Hematology, Hyogo Medical University Hospital, Hyogo, Japan.
  • Matsuoka KI; Department of Hematology and Oncology, Okayama University Hospital, Okayama, Japan.
  • Eto T; Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan.
  • Kanda Y; Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan.
  • Fukuda T; Division of Hematology, Jichi Medical University, Tochigi, Japan.
  • Atsuta Y; Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan.
  • Onishi Y; Japanese Data Center for Hematopoietic Cell Transplantation, Aichi, Japan.
Ann Hematol ; 103(8): 3121-3133, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38750374
ABSTRACT
The impact of absolute neutrophil count (ANC) before allogenic hematopoietic stem cell transplantation (HSCT) on the outcomes for patients with aplastic anemia (AA) remains unclear. We retrospectively evaluated the relationship between ANC before transplantation and patient outcomes, involving 883 adult Japanese patients with AA who underwent allogeneic HSCT as their first transplantation between 2008 and 2020. Patients were divided into three groups based on ANC 0/µL (n = 116); 1-199 (n = 210); and ≥ 200 (n = 557). In the low ANC groups (ANC < 200), patient age was higher, previous anti-thymocyte globulin (ATG) treatments were infrequent, duration from diagnosis to transplantation was shorter, hematopoietic cell transplantation-comorbidity index (HCT-CI) was higher, ATG-based conditioning was used infrequently, and peripheral blood stem cell from related donor and cord blood were used frequently. In multivariate analysis, patient age, previous ATG treatment, HCT-CI, stem cell source, and ANC before transplantation were significantly associated with 5-year overall survival (OS) ("ANC ≥ 200" 80.3% vs. "ANC 1-199" 71.7% vs. "ANC 0" 64.4%). The cumulative incidence of bacterial infection, invasive fungal disease, and early death before engraftment were significantly higher in the low ANC groups. Among patients with ANC of zero before transplantation, younger patient age, shorter duration from diagnosis to transplantation, HCT-CI of 0, and bone marrow from related donor as stem cell source were significantly associated with better OS. Consequently, ANC before allogeneic HSCT was found to be a significant prognostic factor in adult patients with AA. Physicians should pay attention to ANC before transplantation.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Células Madre Hematopoyéticas / Anemia Aplásica / Neutrófilos Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Hematol Asunto de la revista: HEMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Células Madre Hematopoyéticas / Anemia Aplásica / Neutrófilos Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Hematol Asunto de la revista: HEMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Alemania