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Therapeutic Effect of Desmodium caudatum Extracts on Alleviating Diabetic Nephropathy Mice.
Lin, Hui-Hsuan; Tseng, Chiao-Yun; Yu, Pei-Rong; Ho, Hsiang-Yu; Hsu, Cheng-Chin; Chen, Jing-Hsien.
Afiliación
  • Lin HH; Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung City, Taiwan.
  • Tseng CY; Department of Nutrition, Chung Shan Medical University, No.110, Sec.1, Jiangou N. Rd., South Dist., Taichung City, 40201, Taiwan.
  • Yu PR; Department of Nutrition, Chung Shan Medical University, No.110, Sec.1, Jiangou N. Rd., South Dist., Taichung City, 40201, Taiwan.
  • Ho HY; Department of Nutrition, Chung Shan Medical University, No.110, Sec.1, Jiangou N. Rd., South Dist., Taichung City, 40201, Taiwan.
  • Hsu CC; Department of Nutrition, Chung Shan Medical University, No.110, Sec.1, Jiangou N. Rd., South Dist., Taichung City, 40201, Taiwan.
  • Chen JH; Department of Nutrition, Chung Shan Medical University, No.110, Sec.1, Jiangou N. Rd., South Dist., Taichung City, 40201, Taiwan. cjh0828@csmu.edu.tw.
Plant Foods Hum Nutr ; 79(2): 374-380, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38750193
ABSTRACT
Desmodium caudatum extracts (DCE) were investigated for their potential therapeutic effects on diabetic nephropathy (DN). In our study, the high-fat diet (HFD) / streptozotocin (STZ)-induced DN model in C57BL/6 mice was treated with 100 mg/kg, 200 mg/kg DCE. The results showed that DCE decreased biochemical parameters and proteinuria levels. The kidney sections staining indicated that DCE treatment recovered glomerular atrophy and alleviated lipid droplets in the glomerular. Additionally, DCE inhibited lipid and glycogen accumulation down-regulated the expression of sterol regulatory element-binding protein 1 (SREBP1) and fatty acid synthase (FAS) proteins. DCE also reduced collagenous fibrous tissue and the expression of transforming growth factor-ß1 (TGF-ß1) and alpha-smooth muscle actin (α-SMA) through Masson's trichrome staining and immunohistochemical analysis. We found that DCE alleviated hydroxyproline content, and epithelial-mesenchymal transition (EMT). Besides, the results shown that DCE enhanced the antioxidant enzymes to mitigate fibrosis by reducing oxidative stress. In conclusion, our study provided evidence of the protective effect of DCE which down-regulated hyperglycemia, hyperlipidemia and inhibition of TGF-ß1 and EMT pathway but elevated antioxidant, suggesting its therapeutic implication for DN.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extractos Vegetales / Estrés Oxidativo / Nefropatías Diabéticas / Proteína 1 de Unión a los Elementos Reguladores de Esteroles / Factor de Crecimiento Transformador beta1 / Dieta Alta en Grasa / Ratones Endogámicos C57BL Límite: Animals Idioma: En Revista: Plant Foods Hum Nutr Asunto de la revista: BOTANICA / CIENCIAS DA NUTRICAO Año: 2024 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Países Bajos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extractos Vegetales / Estrés Oxidativo / Nefropatías Diabéticas / Proteína 1 de Unión a los Elementos Reguladores de Esteroles / Factor de Crecimiento Transformador beta1 / Dieta Alta en Grasa / Ratones Endogámicos C57BL Límite: Animals Idioma: En Revista: Plant Foods Hum Nutr Asunto de la revista: BOTANICA / CIENCIAS DA NUTRICAO Año: 2024 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Países Bajos