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IFN-α affects Th17/Treg cell balance through c-Maf and associated with the progression of EBV- SLE.
Zhang, Yue; Wang, Jiachao; Fang, Yaqi; Liang, Wenzhang; Lei, Lingyan; Wang, Junhai; Gao, Xue; Ma, Cuiqing; Li, Miao; Guo, Huifang; Wei, Lin.
Afiliación
  • Zhang Y; Department of Immunology, Hebei Medical University, Shijiazhuang, Hebei, China; Key Laboratory of Immune mechanism and Intervention on Serious Disease in Hebei Province, Shijiazhuang, Hebei, China; Department of Rheumatology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, Chin
  • Wang J; Department of Immunology, Hebei Medical University, Shijiazhuang, Hebei, China; Key Laboratory of Immune mechanism and Intervention on Serious Disease in Hebei Province, Shijiazhuang, Hebei, China.
  • Fang Y; Department of Immunology, Hebei Medical University, Shijiazhuang, Hebei, China; Key Laboratory of Immune mechanism and Intervention on Serious Disease in Hebei Province, Shijiazhuang, Hebei, China.
  • Liang W; Department of Immunology, Hebei Medical University, Shijiazhuang, Hebei, China; Key Laboratory of Immune mechanism and Intervention on Serious Disease in Hebei Province, Shijiazhuang, Hebei, China.
  • Lei L; Department of Rheumatology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
  • Wang J; Department of Immunology, Hebei Medical University, Shijiazhuang, Hebei, China; Key Laboratory of Immune mechanism and Intervention on Serious Disease in Hebei Province, Shijiazhuang, Hebei, China.
  • Gao X; Department of Immunology, Hebei Medical University, Shijiazhuang, Hebei, China; Key Laboratory of Immune mechanism and Intervention on Serious Disease in Hebei Province, Shijiazhuang, Hebei, China.
  • Ma C; Department of Immunology, Hebei Medical University, Shijiazhuang, Hebei, China; Key Laboratory of Immune mechanism and Intervention on Serious Disease in Hebei Province, Shijiazhuang, Hebei, China.
  • Li M; Department of Immunology, Hebei Medical University, Shijiazhuang, Hebei, China; Key Laboratory of Immune mechanism and Intervention on Serious Disease in Hebei Province, Shijiazhuang, Hebei, China.
  • Guo H; Department of Rheumatology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. Electronic address: guohfch@126.com.
  • Wei L; Department of Immunology, Hebei Medical University, Shijiazhuang, Hebei, China; Key Laboratory of Immune mechanism and Intervention on Serious Disease in Hebei Province, Shijiazhuang, Hebei, China. Electronic address: weilin@hebmu.edu.cn.
Mol Immunol ; 171: 22-35, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38749236
ABSTRACT

OBJECTIVES:

Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disease, of which the pathogens is remains obscure. Viral infection, particularly Epstein Barr viru (EBV) infection, has been considered a common pathogenic factor. This study suggests that c-Maf may be an important target in T cell differentiation during SLE progression, providing a potentially new perspective on the role of viral infection in the pathogenesis of autoimmune diseases.

METHODS:

Cytokines of EBV-infected SLE patients were measured by ELISA and assessed in conjunction with their clinical data. IFN-α, c-Maf, and the differentiation of Th17/Treg cells in SLE patients and MRL/LPR mice were analyzed using FCM, WB, RT-PCR, etc. Following the infection of cells and mice with EBV or viral mimic poly (dAdT), the changes of the aforementioned indicators were investigated. The relationship among IFN-α, STAT3, c-Maf and Th17 cells was determined by si-RNA technique.

RESULTS:

Many SLE patients are found to be complicated by viral infections; Further, studies have demonstrated that viral infection, especially EBV, is involved in SLE development. This study showed that viral infections might promote IFN-α secretion, inhibit c-Maf expression by activating STAT3, increase Th17 cell differentiation, and lead to the immune imbalance of Th17/Treg cells, thus playing a role in the onset and progression of SLE.

CONCLUSION:

This study demonstrates that EBV infections may contribute to SLE development by activating STAT3 through IFN-α, inhibiting c-Maf, and causing Th17/Treg immune imbalance. Our work provided a new insight into the pathogenesis and treatment of SLE.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Interferón-alfa / Linfocitos T Reguladores / Herpesvirus Humano 4 / Ratones Endogámicos MRL lpr / Infecciones por Virus de Epstein-Barr / Proteínas Proto-Oncogénicas c-maf / Células Th17 / Lupus Eritematoso Sistémico Límite: Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Mol Immunol Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Interferón-alfa / Linfocitos T Reguladores / Herpesvirus Humano 4 / Ratones Endogámicos MRL lpr / Infecciones por Virus de Epstein-Barr / Proteínas Proto-Oncogénicas c-maf / Células Th17 / Lupus Eritematoso Sistémico Límite: Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Mol Immunol Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido