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Volumetric microscopy of cerebral arteries with a miniaturized optical coherence tomography imaging probe.
Pereira, Vitor M; Lylyk, Pedro; Cancelliere, Nicole; Lylyk, Pedro N; Lylyk, Ivan; Anagnostakou, Vania; Bleise, Carlos; Nishi, Hidehisa; Epshtein, Mark; King, Robert M; Shazeeb, Mohammed Salman; Puri, Ajit S; Liang, Conrad W; Hanel, Ricardo A; Spears, Julian; Marotta, Thomas R; Lopes, Demetrius K; Gounis, Matthew J; Ughi, Giovanni J.
Afiliación
  • Pereira VM; Department of Surgery, Division of Neurosurgery, St Michael's Hospital, Toronto, ON M5B 1W8, Canada.
  • Lylyk P; RADIS Lab, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON M5B 1W8, Canada.
  • Cancelliere N; Department of Interventional Neuroradiology, Clínica Sagrada Familia, Buenos Aires, CABA C1426, Argentina.
  • Lylyk PN; Department of Surgery, Division of Neurosurgery, St Michael's Hospital, Toronto, ON M5B 1W8, Canada.
  • Lylyk I; RADIS Lab, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON M5B 1W8, Canada.
  • Anagnostakou V; Department of Interventional Neuroradiology, Clínica Sagrada Familia, Buenos Aires, CABA C1426, Argentina.
  • Bleise C; Department of Interventional Neuroradiology, Clínica Sagrada Familia, Buenos Aires, CABA C1426, Argentina.
  • Nishi H; Department of Radiology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
  • Epshtein M; Department of Interventional Neuroradiology, Clínica Sagrada Familia, Buenos Aires, CABA C1426, Argentina.
  • King RM; Department of Surgery, Division of Neurosurgery, St Michael's Hospital, Toronto, ON M5B 1W8, Canada.
  • Shazeeb MS; RADIS Lab, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON M5B 1W8, Canada.
  • Puri AS; Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto 606-8303, Japan.
  • Liang CW; Department of Radiology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
  • Hanel RA; Department of Radiology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
  • Spears J; Department of Radiology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
  • Marotta TR; Department of Radiology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
  • Lopes DK; Department of Neurosurgery, Kaiser Permanente Fontana Medical Center, Fontana, CA 92335, USA.
  • Gounis MJ; Lyerly Neurosurgery, Baptist Medical Center Jacksonville, Jacksonville, FL 32207, USA.
  • Ughi GJ; Department of Surgery, Division of Neurosurgery, St Michael's Hospital, Toronto, ON M5B 1W8, Canada.
Sci Transl Med ; 16(747): eadl4497, 2024 May 15.
Article en En | MEDLINE | ID: mdl-38748771
ABSTRACT
Endovascular interventions are increasingly becoming the preferred approach for treating strokes and cerebral artery diseases. These procedures rely on sophisticated angiographical imaging guidance, which encounters challenges because of limited contrast and spatial resolution. Achieving a more precise visualization of the underlying arterial pathology and neurovascular implants is crucial for accurate procedural decision-making. In a human study involving 32 patients, we introduced the clinical application of a miniaturized endovascular neuro optical coherence tomography (nOCT) imaging probe. This technology was designed to navigate the tortuous paths of the cerebrovascular circulation and to offer high-resolution imaging in situ. The nOCT probe is compatible with standard neurovascular microcatheters, integrating with the procedural workflow used in clinical routine. Equipped with a miniaturized optical fiber and a distal lens, the probe illuminates the tissue and collects the backscattered, near-infrared light. While rotating the fiber and the lens at high speed, the probe is rapidly retracted, creating a spiral-shaped light pattern to comprehensively capture the arterial wall and implanted devices. Using nOCT, we demonstrated volumetric microscopy of cerebral arteries in patients undergoing endovascular procedures. We imaged the anterior and posterior circulation of the brain, including distal segments of the internal carotid and middle-cerebral arteries, as well as the vertebral, basilar, and posterior cerebral arteries. We captured a broad spectrum of neurovascular pathologies, such as brain aneurysms, ischemic stroke, arterial stenoses, dissections, and intracranial atherosclerotic disease. nOCT offered artifact-free, high-resolution visualizations of intracranial artery pathology and neurovascular devices.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arterias Cerebrales / Tomografía de Coherencia Óptica Límite: Humans Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arterias Cerebrales / Tomografía de Coherencia Óptica Límite: Humans Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos