The protective role of endothelial GLUT1 in ischemic stroke.
Brain Behav
; 14(5): e3536, 2024 May.
Article
en En
| MEDLINE
| ID: mdl-38747733
ABSTRACT
OBJECTIVE:
To provide thorough insight on the protective role of endothelial glucose transporter 1 (GLUT1) in ischemic stroke.METHODS:
We comprehensively review the role of endothelial GLUT1 in ischemic stroke by narrating the findings concerning biological characteristics of GLUT1 in brain in depth, summarizing the changes of endothelial GLUT1 expression and activity during ischemic stroke, discussing how GLUT1 achieves its neuroprotective effect via maintaining endothelial function, and identifying some outstanding blind spots in current studies.RESULTS:
Endothelial GLUT1 maintains persistent high glucose and energy requirements of the brain by transporting glucose through the blood-brain barrier, which preserves endothelial function and is beneficial to stroke prognosis.CONCLUSION:
This review underscores the potential involvement of GLUT1 trafficking, activity modulation, and degradation, and we look forward to more clinical and animal studies to illuminate these mechanisms.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Transportador de Glucosa de Tipo 1
/
Accidente Cerebrovascular Isquémico
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Brain Behav
Año:
2024
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Estados Unidos