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TASL mediates keratinocyte differentiation by regulating intracellular calcium levels and lysosomal function.
Park, Ji Yeong; Kim, Hyeng-Soo; Hyung, Hyejin; Jang, Soyeon; Ko, Jiwon; Lee, Jin Hong; Kim, Si-Yong; Park, Song; Yi, Junkoo; Park, Sijun; Lim, Su-Geun; Kim, Seonggon; Lee, Sanggyu; Kim, Myoung Ok; Jang, Soyoung; Ryoo, Zae Young.
Afiliación
  • Park JY; School of Life Sciences, BK21 FOUR KNU Creative BioResearch Group, Kyungpook National University, Daegu, 41566, Republic of Korea.
  • Kim HS; Institute of Life Science and Biotechnology, Kyungpook National University, Daegu, 41566, Republic of Korea. grayciel@knu.ac.kr.
  • Hyung H; School of Life Sciences, BK21 FOUR KNU Creative BioResearch Group, Kyungpook National University, Daegu, 41566, Republic of Korea.
  • Jang S; Institute of Life Science and Biotechnology, Kyungpook National University, Daegu, 41566, Republic of Korea.
  • Ko J; Institute of Life Science and Biotechnology, Kyungpook National University, Daegu, 41566, Republic of Korea.
  • Lee JH; School of Life Sciences, BK21 FOUR KNU Creative BioResearch Group, Kyungpook National University, Daegu, 41566, Republic of Korea.
  • Kim SY; School of Life Sciences, BK21 FOUR KNU Creative BioResearch Group, Kyungpook National University, Daegu, 41566, Republic of Korea.
  • Park S; Division of Animal Science, Gyeongsang National University, Jinju, 52828, Republic of Korea.
  • Yi J; Institute of Agriculture and Life Science (IALS), Gyeongsang National University, Jinju, 52828, Republic of Korea.
  • Park S; School of Animal Life Convergence Science, Hankyong National University, Anseong, 17579, Republic of Korea.
  • Lim SG; Institute of Life Science and Biotechnology, Kyungpook National University, Daegu, 41566, Republic of Korea.
  • Kim S; Institute of Life Science and Biotechnology, Kyungpook National University, Daegu, 41566, Republic of Korea.
  • Lee S; Preclinical Research Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Republic of Korea.
  • Kim MO; School of Life Sciences, BK21 FOUR KNU Creative BioResearch Group, Kyungpook National University, Daegu, 41566, Republic of Korea.
  • Jang S; Department of Animal Science and Biotechnology, Research Institute for Innovative Animal Science, Kyungpook National University, Sangju-si, Gyeongsang buk-do, 37224, Republic of Korea.
  • Ryoo ZY; School of Life Sciences, BK21 FOUR KNU Creative BioResearch Group, Kyungpook National University, Daegu, 41566, Republic of Korea. wkdthdud21@naver.com.
Sci Rep ; 14(1): 10978, 2024 05 14.
Article en En | MEDLINE | ID: mdl-38744928
ABSTRACT
Maintaining epidermal homeostasis relies on a tightly organized process of proliferation and differentiation of keratinocytes. While past studies have primarily focused on calcium regulation in keratinocyte differentiation, recent research has shed light on the crucial role of lysosome dysfunction in this process. TLR adaptor interacting with SLC15A4 on the lysosome (TASL) plays a role in regulating pH within the endo-lysosome. However, the specific role of TASL in keratinocyte differentiation and its potential impact on proliferation remains elusive. In our study, we discovered that TASL deficiency hinders the proliferation and migration of keratinocytes by inducing G1/S cell cycle arrest. Also, TASL deficiency disrupts proper differentiation process in TASL knockout human keratinocyte cell line (HaCaT) by affecting lysosomal function. Additionally, our research into calcium-induced differentiation showed that TASL deficiency affects calcium modulation, which is essential for keratinocyte regulation. These findings unveil a novel role of TASL in the proliferation and differentiation of keratinocytes, providing new insights into the intricate regulatory mechanisms of keratinocyte biology.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Queratinocitos / Diferenciación Celular / Calcio / Péptidos y Proteínas de Señalización Intracelular / Proliferación Celular / Lisosomas Límite: Humans Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Queratinocitos / Diferenciación Celular / Calcio / Péptidos y Proteínas de Señalización Intracelular / Proliferación Celular / Lisosomas Límite: Humans Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido